Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Eukaryotic Gene Expression
Factor de Impacto: 1.841 Factor de Impacto de 5 años: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i1.10
pages 1-16

mTOR Signaling in Cancer Cell Motility and Tumor Metastasis

Hongyu Zhou
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USA
Shile Huang
Department of Biochemistry and Molecular Biology and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, USA

SINOPSIS

Tumor cell migration is a key step in the formation of cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serinethreonine kinase, has been intensely studied for over a decade as a central regulator of cell growth, proliferation, differentiation, and survival. Recent data have shown that mTOR also plays a critical role in the regulation of tumor cell motility and cancer metastasis. Here, we briefly review recent advances regarding mTOR signaling in tumor cell motility. We also discuss recent findings about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell motility in vitro and metastasis in vivo.


Articles with similar content:

Molecular Targets for Suppression of Metastasis: Recent Cellular Observations
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 1
Siro Simizu, Yuki Niwa
A New Linkage between the Tumor Suppressor RKIP and Autophagy: Targeted Therapeutics
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 5-6
Yuhao Wang, Benjamin Bonavida
Kruppel-Like Factor 4: From Physiological Functions to Tumor Therapy
Forum on Immunopathological Diseases and Therapeutics, Vol.7, 2016, issue 1-2
Peng Li, Ruocong Zhao, Yunxin Lai
The Ron Receptor Tyrosine Kinase: A Key Regulator of Inflammation and Cancer Progression
Critical Reviews™ in Immunology, Vol.33, 2013, issue 6
Pamela A. Hankey, Xin Wang
Gene Regulation Associated with Apoptosis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Barbara A. Osborne, Birgit M. Jehn