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Critical Reviews™ in Eukaryotic Gene Expression
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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020035836
pages 447-456

Prognostic Value of Differentially Expressed LncRNAs in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis

Dilihumaer Tuluhong
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Wangmu Dunzhu
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Jingjie Wang
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Tao Chen
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Hanjun Li
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Qiurong Li
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Shaohua Wang
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China

SINOPSIS

Breast cancer is the most common cancer in women worldwide and can be classified into multiple subtypes, including triple-negative breast cancer (TNBC). TNBC is more aggressive than other types of breast cancer and has a poor prognosis. However, excluding chemotherapy, the treatment of TNBC does not involve targeted therapy. The dysregulated expression of lncRNAs plays a vital role in the development of numerous cancers. Thus, the aim of this meta-analysis is to determine the functional roles of lncRNAs in TNBC. We performed a systematic search for articles related to TNBC using multiple online databases, including PubMed, EMBASE, Web of Science, and Science-Direct. We collated pooled hazard ratios with 95% confidence interval to estimate the prognostic value of lncRNAs. We assessed the quality of studies using the Newcastle-Ottawa scale. Data were collected from cohort studies that compared overall survival, disease-free survival, and relapse-free survival between patients with high and patients with low expression of lncRNAs. Using 2,192 samples from 21 studies, we observed a correlation between poor prognosis and the upregulation of 14 lncRNAs (LINC00173, HUMT, HOTAIR, LUCAT1, HIF1A-AS2, ZEB2-AS1, NAMPT-AS, DANCR, LINC01638, ZNF469-3, AFAP1-AS1, ANRIL, MALAT1, and HULC) and downregulation of four lncRNAs (MIR503HG, NEF, TC0NS_12_00002973, and GAS5). The pooled hazard ratios for the correlation between differentially expressed lncRNAs and overall, disease-free, and relapse-free survival were 2.38 (2.03-2.78), 2.19 (1.51-3.16), and 3.19 (0.81-12.53), respectively. This meta-analysis shows that the expression of candidate lncRNAs may reliably predict the prognosis of patients with TNBC.

REFERENCIAS

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7-30.

  2. DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Goding Sauer A, Jemal A, Siegel RL. Breast cancer 16. statistics, 2019. CA Cancer J Clin. 2019;69(6):438-51.

  3. Bergin ART, Loi S. Triple-negative breast cancer: Recent treatment advances. F1000Res. 2019;8:F1000 Faculty Rev-1342.

  4. Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21(11):1253-61.

  5. Rathinasamy B, Velmurugan BK. Role of lncRNAs in the cancer development and progression and their regulation by various phytochemicals. Biomed Pharmacother. 2018;102:242-8.

  6. Wang Q, Gao S, Li H, Lv M, Lu C. Long noncoding RNAs (lncRNAs) in triple negative breast cancer. J Cell Physiol. 19. 2017;232(12):3226-33.

  7. Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester, UK: Wiley-Blackwell; 2008. p. 633-49.

  8. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche 20. PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1-34.

  9. Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.

  10. Zheng S, Yang L, Zou Y, Liang JY, Liu P, Gao G, Yang A, Tang H, Xie X. Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancer. J Hematol Oncol. 2020;13(1):17.

  11. Fan H, Yuan J, Li X, Ma Y, Wang X, Xu B, Li X. LncRNA LINC00173 enhances triple-negative breast cancer progression by suppressing miR-490-3p expression. Biomed Pharmacother. 2020;125:109987.

  12. Zhang H, Zhang N, Liu Y, Su P, Liang Y, Li Y, Wang X, Chen T, Song X, Sang Y, Duan Y, Zhang J, Wang L, Chen B, Zhao W, Guo H, Liu Z, Hu G, Yang Q. Epigenetic regulation of NAMPT by NAMPT-AS drives metastatic progression in triple-negative breast cancer. Cancer Res. 2019;79(13):3347-59.

  13. Zhang G, Li H, Sun R, Li P, Yang Z, Liu Y, Wang Z, Yang Y, Yin C. Long non-coding RNA ZEB2-AS1 promotes the proliferation, metastasis and epithelial mesenchymal transition in triple-negative breast cancer by epigenetically activating ZEB2. J Cell Mol Med. 2019;23(5):3271-9.

  14. Yan J, Wang R, Wu Z. LncRNA TC0NS_l2_00002973 correlates with less advanced tumor stage and favorable survival, and also inhibits cancer cells proliferation while enhancing apoptosis in triple-negative breast cancer. J BUON. 2019;24(2):535-42.

  15. Wang Y, Zhang G, Han J. HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer. J Cell Biochem. 2019;120(6):10513-8.

  16. Tao W, Wang C, Zhu B, Zhang G, Pang D. LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: LncRNA DANCR contributes to tumor progression. Biosci Rep. 2019;39(4):BSR20181618.

  17. Song X, Liu Z, Yu Z. LncRNA NEF is downregulated in triple negative breast cancer and correlated with poor prognosis. Acta Biochim Biophys Sin (Shanghai). 2019;51(4):386-92.

  18. Mou E, Wang H. LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702. Biosci Rep. 2019;39(9):BSR20190489.

  19. Liang H, Huang W, Wang Y, Ding L, Zeng L. Overexpression of MiR-146a-5p upregulates lncRNA HOTAIR in triple-negative breast cancer cells and predicts poor prognosis. Technol Cancer Res Treat. 2019;18. doi: 10.1177/1533033819882949.

  20. Fu J, Dong G, Shi H, Zhang J, Ning Z, Bao X, Liu C, Hu J, Liu M, Xiong B. LncRNA MIR503HG inhibits cell migration and invasion via miR-103/0LFM4 axis in triple negative breast cancer. J Cell Mol Med. 2019;23(7):4738-45.

  21. Zhang K, Liu P, Tang H, Xie X, Kong Y, Song C, Qiu X, Xiao X. AFAP1-AS1 promotes epithelial-mesenchymal transition and tumorigenesis through Wnt/p-catenin signaling pathway in triple-negative breast cancer. Front Pharmacol. 2018;9:1248.

  22. Tang J, Zhong G, Zhang H, Yu B, Wei F, Luo L, Kang Y, Wu J, Jiang J, Li Y, Wu S, Jia Y, Liang X, Bi A. LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA. Cell Death Dis. 2018;9(12):1167.

  23. Li S, Zhou J, Wang Z, Wang P, Gao X, Wang Y. Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p. Biomed Pharmacother. 2018;104:451-7.

  24. Zuo Y, Li Y, Zhou Z, Ma M, Fu K. Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer. Biomed Pharmacother. 2017;95:922-8.

  25. Xu S-T, Xu JH, Zheng ZR, Zhao QQ, Zeng XS, Cheng SX, Liang YH, Hu QF. Long non-coding RNA AN-RIL promotes carcinogenesis via sponging miR-199a in triple-negative breast cancer. Biomed Pharmacother. 2017;96:14-21.

  26. Sha S, Yuan D, Liu Y, Han B, Zhong N. Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression. Biol Open. 2017;6(9):1310-6.

  27. Shi F, Xiao F, Ding P, Qin H, Huang R. Long noncoding RNA highly up-regulated in liver cancer predicts unfavorable outcome and regulates metastasis by MMPs in triple-negative breast cancer. Arch Med Res. 2016;47(6):446-53.

  28. Li L, Yang Z, Wang Y, Zhang Y, Zhou Y, Wang W, Lin L, Su W, Yang Z. Long non-coding RNA MALAT1 promote triple-negative breast cancer progression by regulating miR-204 expression. Int J Clin Exp Pathol. 2016;9(2):969-77.

  29. Wang PS, Chou CH, Lin CH, Yao YC, Cheng HC, Li HY, Chuang YC, Yang CN, Ger LP, Chen YC, Lin FC, Shen TL, Hsiao M, Lu PJ. A novel long non-coding RNA linc-ZNF469-3 promotes lung metastasis through miR-574-5p-ZEB1 axis in triple negative breast cancer. Oncogene. 2018;37(34):4662-78.

  30. Luo L, Tang H, Ling L, Li N, Jia X, Zhang Z, Wang X, Shi L, Yin J, Qiu N, Liu H, Song Y, Luo K, Li H, He Z, Zheng G, Xie X. LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer. Oncogene. 2018;37(47):6166-79.

  31. Prabhu KS, Raza A, Karedath T, Raza SS, Fathima H, Ahmed EI, Kuttikrishnan S, Therachiyil L, Kulinski M, Dermime S, Junejo K, Steinhoff M, Uddin S. Non-coding RNAs as regulators and markers for targeting of breast cancer and cancer stem cells. Cancers (Basel). 2020;12(2):351.

  32. Mozdarani H, Ezzatizadeh V, Rahbar Parvaneh R. The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment. J Transl Med. 2020;18(1):152.

  33. Yang X, Luo E, Liu X, Han B, Yu X, Peng X. Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway. BMC Cancer. 2016;16:423.

  34. Han B, Peng X, Cheng D, Zhu Y, Du J, Li J, Yu X. Delphinidin suppresses breast carcinogenesis through the HOTAIR/microRNA-34a axis. Cancer Sci. 2019; 110(10):3089-97.

  35. Bradburn MJ, Clark TG, Love SB, Altman DG. Survival analysis part II: Multivariate data analysis - an introduction to concepts and methods. Br J Cancer. 2003;89(3):431-6.

  36. Tian T, Gong Z, Wang M, Hao R, Lin S, Liu K, Guan F, Xu P, Deng Y, Song D, Li N, Wu Y, Dai Z. Identification of long non-coding RNA signatures in triple-negative breast cancer. Cancer Cell Int. 2018;18:103.


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