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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Imprimir: 1045-4403
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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020035836
pages 447-456

Prognostic Value of Differentially Expressed LncRNAs in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis

Dilihumaer Tuluhong
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Wangmu Dunzhu
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Jingjie Wang
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Tao Chen
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Hanjun Li
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Qiurong Li
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
Shaohua Wang
Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China


Breast cancer is the most common cancer in women worldwide and can be classified into multiple subtypes, including triple-negative breast cancer (TNBC). TNBC is more aggressive than other types of breast cancer and has a poor prognosis. However, excluding chemotherapy, the treatment of TNBC does not involve targeted therapy. The dysregulated expression of lncRNAs plays a vital role in the development of numerous cancers. Thus, the aim of this meta-analysis is to determine the functional roles of lncRNAs in TNBC. We performed a systematic search for articles related to TNBC using multiple online databases, including PubMed, EMBASE, Web of Science, and Science-Direct. We collated pooled hazard ratios with 95% confidence interval to estimate the prognostic value of lncRNAs. We assessed the quality of studies using the Newcastle-Ottawa scale. Data were collected from cohort studies that compared overall survival, disease-free survival, and relapse-free survival between patients with high and patients with low expression of lncRNAs. Using 2,192 samples from 21 studies, we observed a correlation between poor prognosis and the upregulation of 14 lncRNAs (LINC00173, HUMT, HOTAIR, LUCAT1, HIF1A-AS2, ZEB2-AS1, NAMPT-AS, DANCR, LINC01638, ZNF469-3, AFAP1-AS1, ANRIL, MALAT1, and HULC) and downregulation of four lncRNAs (MIR503HG, NEF, TC0NS_12_00002973, and GAS5). The pooled hazard ratios for the correlation between differentially expressed lncRNAs and overall, disease-free, and relapse-free survival were 2.38 (2.03-2.78), 2.19 (1.51-3.16), and 3.19 (0.81-12.53), respectively. This meta-analysis shows that the expression of candidate lncRNAs may reliably predict the prognosis of patients with TNBC.


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