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Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Progress Toward Skeletal Gene Therapy

Volumen 14, Edición 1&2, 2004, 48 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v14.i12.60
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SINOPSIS

Skeletal gene therapy is an attractive new approach to the treatment of bone disorders. Impressive advances in our knowledge of the molecular genetic basis of skeletal disorders and fracture healing have led to the development of novel therapeutics based on ectopic expression of one or more genes in patient cells that can influence repair or regenerative processes in bone. Although still a relatively immature field, proof-of-principle for enhanced bone formation through skeletal gene therapy has already been established. The challenge now is to more precisely define optimal cellular targets and therapeutic genes, and to develop safe and efficient ways to deliver therapeutic genes to target cells. In this review, we will highlight some of the exciting advances that have been made in skeletal gene therapy in recent years, with a focus on treatment of localized skeletal lesions. Strengths and weaknesses of current approaches will be discussed, as will strategies for improved safety and therapeutic outcome in the future. Skeletal gene therapy can have an enormous impact on patient care. The next 5 years will present us with unparalleled opportunities to develop more effective therapeutic strategies and overcome obstacles presented by current gene transfer technologies.

CITADO POR
  1. Varkey Mathew, Gittens Sebastien A, Uludag Hasan, Growth factor delivery for bone tissue repair: an update, Expert Opinion on Drug Delivery, 1, 1, 2004. Crossref

  2. Lau K.-H. William, Gysin Reinhard, Chen Shin-Tai, Wergedal Jon E., Baylink David J., Mohan Subburaman, Marrow Stromal Cell-Based Cyclooxygenase 2 Ex Vivo Gene-Transfer Strategy Surprisingly Lacks Bone-Regeneration Effects and Suppresses the Bone-Regeneration Action of Bone Morphogenetic Protein 4 in a Mouse Critical-Sized Calvarial Defect Model, Calcified Tissue International, 85, 4, 2009. Crossref

  3. Giannoudis Peter V., Tzioupis Christopher C., Tsirids Eleftherios, Gene therapy in orthopaedics, Injury, 37, 1, 2006. Crossref

  4. SUMNER D. R., TURNER T. M., URBAN R. M., VIRDI A. S., INOUE N., ADDITIVE ENHANCEMENT OF IMPLANT FIXATION FOLLOWING COMBINED TREATMENT WITH RHTGF-β2 AND RHBMP-2 IN A CANINE MODEL, The Journal of Bone and Joint Surgery-American Volume, 88, 4, 2006. Crossref

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