Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
The Route to HPV-Associated Neoplastic Transformation: A Review of the Literature
SINOPSIS
Human papillomaviruses (HPVs)−small, nonenveloped viruses with double-stranded circular DNA−are believed to have a role in the progression of cancer. However, the exact mechanisms are not well established. The interference of HPV proteins, especially E6 and E7, in the cell cycle is considered to be the main pathway. It is still questioned whether the expression of these proteins or the viral load is more important in neoplastic transformation. Furthermore, HPV is believed to adapt mechanisms to evade the host cell immune system; persistent HPV infection may also play a role in oncogenic transformation by causing genomic instability and local immune suppression. These factors may cause accumulation of genomic alterations within the host cell and integration of the viral genome into the host genome. In recent years, epigenetic modifications, such as methylation, have also been considered to take part in neoplastic transformation. All of these alterations to the genome may be favorable to the development of cancer. This article highlights the association of HPV in neoplastic transformation and cancer progression.
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Todorova A., Schwierzeck V., Turek D., Zink A., Schwerdtfeger C., Kaliebe K., Spinner C.D., Traidl‐Hoffmann C., Evaluation of anal carcinoma screening in male and femaleHIVpatients at an interdisciplinaryHIVtherapy centre, Journal of the European Academy of Dermatology and Venereology, 33, 8, 2019. Crossref
-
Gupta Ishita, Al Farsi Halema, Jabeen Ayesha, Skenderi Faruk, Al-Thawadi Hamda, AlAhmad Yaman M., Abdelhafez Ibrahim, Al Moustafa Ala-Eddin, Vranic Semir, High-Risk Human Papillomaviruses and Epstein–Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status, Pathogens, 9, 6, 2020. Crossref
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Chen Xiangfan, Yan Hong, Cao Yingnan, Li Shiyue, Yang Ningxi, Li Xiaoyan, Epidemiological investigation on the cervical health of lesbians in Beijing, China, Journal of International Medical Research, 48, 2, 2020. Crossref
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Nagi Karim, Gupta Ishita, Jurdi Nawaf, Jabeen Ayesha, Yasmeen Amber, Batist Gerald, Vranic Semir, Al-Moustafa Ala-Eddin, High-risk human papillomaviruses and Epstein–Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study, Cancer Cell International, 21, 1, 2021. Crossref
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Asti Lindsey, Hopley Colin, Avelis Cameron, Bartsch Sarah M., Mueller Leslie E., Domino Molly, Cox Sarah N., Andrews Jeffrey C., Randall Samuel L., Stokes-Cawley Owen J., Asjes Caitlin, Lee Bruce Y., The Potential Clinical and Economic Value of a Human Papillomavirus Primary Screening Test That Additionally Identifies Genotypes 31, 45, 51, and 52 Individually, Sexually Transmitted Diseases, 48, 5, 2021. Crossref
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Hariprasad Roopa, Tulsyan Sonam, Babu Roshani, Dhanasekaran Kavitha, Thakur Nisha, Hussain Showket, Tripathi Richa, Sreenivas Vishnubhatla, Sharma Shashi, Sriram Latha, Singh Shalini, Mehrotra Ravi, Evaluation of a Chip-Based, Point-of-Care, Portable, Real-Time Micro PCR Analyzer for the Detection of High-Risk Human Papillomavirus in Uterine Cervix in India, JCO Global Oncology, 6, 2020. Crossref
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Miachieo Nounechutuo, Yepthomi Nito, Vise Esther, Jamir Bendangtoshi, Momin Rebeki, Jimo Kanili, Cervical cancer screening using liquid-based cytology (LBC) in a secondary care hospital in Northeast India, Indian Journal of Pathology and Oncology, 9, 1, 2022. Crossref
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Gupta Ishita, Ulamec Monika, Peric-Balja Melita, Ramic Snjezana, Al Moustafa Ala-Eddin, Vranic Semir, Al-Farsi Halema F., Presence of high-risk HPVs, EBV, and MMTV in human triple-negative breast cancer, Human Vaccines & Immunotherapeutics, 17, 11, 2021. Crossref
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Ma Yanyun, Wang Chunxia, Shi Mengqi, Li Mingshan, Li Lin, Che Tuanjie, Qu Jing, Searching for the methylation sites involved in human papillomavirus type 16 and 18‑positive women with cervical cancer, Molecular and Clinical Oncology, 17, 4, 2022. Crossref