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Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Drugs That Target Gene Expression: An Overview

Volumen 6, Edición 1, 1996, pp. 75-85
DOI: 10.1615/CritRevEukarGeneExpr.v6.i1.50
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SINOPSIS

Over the last few years, it has become apparent that regulation of many normal physiological pathways, as well as the response to a wide variety of disease states, involves specific changes in gene transcription. The concept of drugs that regulate gene transcription is now firmly established. There are multiple, highly effective drugs in widespread use whose primary mechanism of action is to affect gene transcription. A major goal at Oncogene Science is to develop drugs that can modulate the normal physiological responses associated with disease by specifically increasing or decreasing the transcription of key genes. In this article, we review several examples of drugs that have been shown to act by regulating gene transcription and describe the approach Oncogene Science has pioneered.

CITADO POR
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  3. Abdul aziz Ahmad Aizat, MD Salleh MD Salzihan, Mohamad Ibtisam, Bhavaraju Venkata Murali Krishna, Yahya Maya Mazuwin, Zakaria Andee Dzulkarnaen, Gan Siew Hua, Ankathil Ravindran, Single-nucleotide polymorphisms and mRNA expression of CYP1B1 influence treatment response in triple negative breast cancer patients undergoing chemotherapy, Journal of Genetics, 97, 5, 2018. Crossref

  4. Scotto Kathleen W., Ince Tan A., Transcriptional Regulation, in Basic Science of Cancer, 2000. Crossref

  5. Biswas Subhankar, Rao C. Mallikarjuna, Epigenetics in cancer: Fundamentals and Beyond, Pharmacology & Therapeutics, 173, 2017. Crossref

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