Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Hdac-Mediated Control of Endochondral and Intramembranous Ossification
SINOPSIS
Histone deacetylases (Hdacs) remove acetyl groups (CH3CO-) from ε-amino groups in lysine residues within histones and other proteins. This posttranslational (de) modification alters protein stability, protein-protein interactions, and chromatin structure. Hdac activity plays important roles in the development of all organs and tissues, including the mineralized skeleton. Bone is a dynamic tissue that forms and regenerates by two processes: endochondral and intramembranous ossification. Chondrocytes and osteoblasts are responsible for producing the extracellular matrices of skeletal tissues. Several Hdacs contribute to the molecular pathways and chromatin changes that regulate tissue-specific gene expression during chondrocyte and osteoblast specification, maturation, and terminal differentiation. In this review, we summarize the roles of class I and class II Hdacs in chondrocytes and osteoblasts. The effects of small molecule Hdac inhibitors on the skeleton are also discussed.
-
Paradis France-Hélène, Hales Barbara F., Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs, Toxicological Sciences, 131, 1, 2013. Crossref
-
Saki Najmaldin, Farshdousti Hagh Majid, Mortaz Esmaeil, Ardeshiry Lajimi Abdolreza, Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?, Iranian Red Crescent Medical Journal, 15, 8, 2013. Crossref
-
Sinha Krishna M., Zhou Xin, Genetic and molecular control of osterix in skeletal formation, Journal of Cellular Biochemistry, 114, 5, 2013. Crossref
-
Marie Pierre J., Osteoblast dysfunctions in bone diseases: from cellular and molecular mechanisms to therapeutic strategies, Cellular and Molecular Life Sciences, 72, 7, 2015. Crossref
-
Wu Hai, Whitfield Troy W, Gordon Jonathan A R, Dobson Jason R, Tai Phillip W L, van Wijnen Andre J, Stein Janet L, Stein Gary S, Lian Jane B, Genomic occupancy of Runx2 with global expression profiling identifies a novel dimension to control of osteoblastogenesis, Genome Biology, 15, 3, 2014. Crossref
-
Marie Pierre J, Bone Cell Senescence: Mechanisms and Perspectives, Journal of Bone and Mineral Research, 29, 6, 2014. Crossref
-
Kim Hye-Jin, Park Jong-Wan, Lee Kyoung-Hwa, Yoon Haejin, Shin Dong Hoon, Ju Uk-Il, Seok Seung Hyeok, Lim Seung Hyeon, Lee Zang Hee, Kim Hong-Hee, Chun Yang-Sook, Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation, Cell Research, 24, 10, 2014. Crossref
-
Gordon Jonathan A. R., Montecino Martin A., Aqeilan Rami I., Stein Janet L., Stein Gary S., Lian Jane B., Epigenetic Pathways Regulating Bone Homeostasis: Potential Targeting for Intervention of Skeletal Disorders, Current Osteoporosis Reports, 12, 4, 2014. Crossref
-
Holmes Greg, van Bakel Harm, Zhou Xueyan, Losic Bojan, Jabs Ethylin Wang, BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development, Gene Expression Patterns, 17, 1, 2015. Crossref
-
McGee-Lawrence Meghan E., Carpio Lomeli R., Bradley Elizabeth W., Dudakovic Amel, Lian Jane B., van Wijnen Andre J., Kakar Sanjeev, Hsu Wei, Westendorf Jennifer J., Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice, Bone, 66, 2014. Crossref
-
Gordon Jonathan A.R., Stein Janet L., Westendorf Jennifer J., van Wijnen Andre J., Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease, Bone, 81, 2015. Crossref
-
Paradis France-Hélène, Hales Barbara F., The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis, Toxicological Sciences, 148, 1, 2015. Crossref
-
McGee-Lawrence Meghan E, Carpio Lomeli R, Schulze Ryan J, Pierce Jessica L, McNiven Mark A, Farr Joshua N, Khosla Sundeep, Oursler Merry Jo, Westendorf Jennifer J, Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells, Journal of Bone and Mineral Research, 31, 1, 2016. Crossref
-
Ricarte Florante, Nakatani Teruyo, Partridge Nicola, PTH Signaling and Epigenetic Control of Bone Remodeling, Current Molecular Biology Reports, 2, 1, 2016. Crossref
-
Duncan Henry F., Smith Anthony J., Fleming Garry J. P., Partridge Nicola C., Shimizu Emi, Moran Gary P., Cooper Paul R., The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity, Journal of Cellular Physiology, 231, 4, 2016. Crossref
-
Cantley M.D., Zannettino A.C.W., Bartold P.M., Fairlie D.P., Haynes D.R., Histone deacetylases (HDAC) in physiological and pathological bone remodelling, Bone, 95, 2017. Crossref
-
Goldring Steven R., Goldring Mary B., Biology of the Normal Joint, in Kelley and Firestein's Textbook of Rheumatology, 2017. Crossref
-
Park-Min Kyung Hyun, Epigenetic regulation of bone cells, Connective Tissue Research, 58, 1, 2017. Crossref
-
Goldring Mary B., Culley Kirsty L., Wondimu Elisabeth, Otero Miguel, Cartilage and Chondrocytes, in Kelley and Firestein's Textbook of Rheumatology, 2017. Crossref
-
Dai Bingyang, Li Qiangqiang, Song Xiaoxiao, Ge Yuxiang, Wu Jing, Zhang Kaijia, Wang Chao, Zhang Yifeng, Teng Huajian, Li Chaojun, Jiang Qing, Knockdown of Ggps1 in chondrocyte expedites fracture healing by accelerating the progression of endochondral ossification in mice, Journal of Bone and Mineral Metabolism, 36, 2, 2018. Crossref
-
Boyce Brendan F., Zuscik Michael J., Xing Lianping, Biology of Bone and Cartilage, in Genetics of Bone Biology and Skeletal Disease, 2018. Crossref
-
Shimizu Emi, Nakatani Teruyo, He Zhiming, Partridge Nicola C., Parathyroid Hormone Regulates Histone Deacetylase (HDAC) 4 through Protein Kinase A-mediated Phosphorylation and Dephosphorylation in Osteoblastic Cells, Journal of Biological Chemistry, 289, 31, 2014. Crossref
-
Farr Joshua N, Almeida Maria, The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging, Journal of Bone and Mineral Research, 33, 9, 2018. Crossref
-
Xin Frances, Smith Lauren M, Susiarjo Martha, Bartolomei Marisa S, Jepsen Karl J, Shioda Toshihiro, Endocrine-disrupting chemicals, epigenetics, and skeletal system dysfunction: exploration of links using bisphenol A as a model system, Environmental Epigenetics, 4, 2, 2018. Crossref
-
Saad Fawzy Ali, Novel insights into the complex architecture of osteoporosis molecular genetics, Annals of the New York Academy of Sciences, 1462, 1, 2020. Crossref
-
Shreya S., Malavika D., Priya V. Raj, Selvamurugan N., Regulation of Histone Deacetylases by MicroRNAs in Bone, Current Protein & Peptide Science, 20, 4, 2019. Crossref
-
Zhu Yan, Cao Zhenning, Lu Chang, Microfluidic MeDIP-seq for low-input methylomic analysis of mammary tumorigenesis in mice, The Analyst, 144, 6, 2019. Crossref
-
Faulkner Bora, Astleford Kristina, Mansky Kim, Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases, Molecules, 24, 7, 2019. Crossref
-
Elmansi Ahmed M., Hussein Khaled A., Herrero Sergio Mas, Periyasamy-Thandavan Sudharsan, Aguilar-Pérez Alexandra, Kondrikova Galina, Kondrikov Dmitry, Eisa Nada H., Pierce Jessica L., Kaiser Helen, Ding Ke-Hong, Walker Aisha L., Jiang Xue, Bollag Wendy B., Elsalanty Mohammed, Zhong Qing, Shi Xing-ming, Su Yun, Johnson Maribeth, Hunter Monte, Reitman Charles, Volkman Brian F., Hamrick Mark W., Isales Carlos M., Fulzele Sadanand, McGee-Lawrence Meghan E., Hill William D., Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells, Bone Reports, 12, 2020. Crossref
-
Wuelling Manuela, Neu Christoph, Thiesen Andrea M, Kitanovski Simo, Cao Yingying, Lange Anja, Westendorf Astrid M, Hoffmann Daniel, Vortkamp Andrea, Epigenetic Mechanisms Mediating Cell State Transitions in Chondrocytes, Journal of Bone and Mineral Research, 36, 5, 2021. Crossref
-
Liu Nan, Zhang Zhuqiang, Wu Hui, Jiang Yonghua, Meng Lingjun, Xiong Jun, Zhao Zuodong, Zhou Xiaohua, Li Jia, Li Hong, Zheng Yong, Chen She, Cai Tao, Gao Shaorong, Zhu Bing, Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability, Genes & Development, 29, 4, 2015. Crossref
-
Tandon Manish, Gokul Karthiga, Ali Syed A, Chen Zujian, Lian Jane, Stein Gary S, Pratap Jitesh, Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells, Molecular Cancer, 11, 1, 2012. Crossref
-
Crous Anine, Abrahamse Heidi, The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review, Stem Cell Reviews and Reports, 17, 5, 2021. Crossref
-
Galea Gabriel L., Paradise Christopher R., Meakin Lee B., Camilleri Emily T., Taipaleenmaki Hanna, Stein Gary S., Lanyon Lance E., Price Joanna S., van Wijnen Andre J., Dudakovic Amel, Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2, Gene, 763, 2020. Crossref
-
Li Shaowei, Huang Ke-Jung, Wu Jen-Chieh, Hu Michael S., Sanyal Mrinmoy, Hu Min, Longaker Michael T., Lorenz H. Peter, Peripheral Blood-Derived Mesenchymal Stem Cells: Candidate Cells Responsible for Healing Critical-Sized Calvarial Bone Defects, Stem Cells Translational Medicine, 4, 4, 2015. Crossref
-
Gebuijs I.G.E., Metz J.R., Zethof J., Carels C.E.L., Wagener F.A.D.T.G., Von den Hoff J.W., The anti-epileptic drug valproic acid causes malformations in the developing craniofacial skeleton of zebrafish larvae, Mechanisms of Development, 163, 2020. Crossref
-
Torres Haydee M., VanCleave Ashley M., Vollmer Mykayla, Callahan Dakota L., Smithback Austyn, Conn Josephine M., Rodezno-Antunes Tania, Gao Zili, Cao Yuxia, Afeworki Yohannes, Tao Jianning, Selective Targeting of Class I Histone Deacetylases in a Model of Human Osteosarcoma, Cancers, 13, 16, 2021. Crossref
-
Khosla Sundeep, Monroe David G., Farr Joshua N., Osteoporosis and bone loss, in Cellular Senescence in Disease, 2022. Crossref
-
Bradley Elizabeth W., Carpio Lomeli R., Westendorf Jennifer J., Histone Deacetylase 3 Suppression Increases PH Domain and Leucine-rich Repeat Phosphatase (Phlpp)1 Expression in Chondrocytes to Suppress Akt Signaling and Matrix Secretion, Journal of Biological Chemistry, 288, 14, 2013. Crossref
-
Ren Zhitao, Raut Nishikant A., Lawal Temitope O., Patel Shital R., Lee Simon M., Mahady Gail B., Peonidin‐3‐O ‐glucoside and cyanidin increase osteoblast differentiation and reduce RANKL ‐induced bone resorption in transgenic medaka , Phytotherapy Research, 35, 11, 2021. Crossref
-
Khosla Sundeep, Farr Joshua N., Monroe David G., Cellular senescence and the skeleton: pathophysiology and therapeutic implications, Journal of Clinical Investigation, 132, 3, 2022. Crossref
-
Rojas Adriana, Aguilar Rodrigo, Henriquez Berta, Lian Jane B., Stein Janet L., Stein Gary S., van Wijnen Andre J., van Zundert Brigitte, Allende Miguel L., Montecino Martin, Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B, Journal of Biological Chemistry, 290, 47, 2015. Crossref
-
Allas Lyess, Boumédiene Karim, Baugé Catherine, Epigenetic dynamic during endochondral ossification and articular cartilage development, Bone, 120, 2019. Crossref
-
Louvet Loïc, Leterme Damien, Delplace Séverine, Miellot Flore, Marchandise Pierre, Gauthier Véronique, Hardouin Pierre, Chauveau Christophe, Ghali Mhenni Olfa, Sirtuin 1 deficiency decreases bone mass and increases bone marrow adiposity in a mouse model of chronic energy deficiency, Bone, 136, 2020. Crossref