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Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Role of PARP-1 in Host−Pathogen Interaction and Cellular Stress Responses

Volumen 25, Edición 2, 2015, pp. 175-190
DOI: 10.1615/CritRevEukaryotGeneExpr.2015013626
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SINOPSIS

Cells are exposed to diverse stresses; poly(ADP-ribose) polymerase-1 (PARP-1), which processes diverse signals and directs cells to specific fates (survival or death), is a key player in responses to cellular stress. PARP-1 usually uses NAD+ as a donor of ADP-ribose units to regulate the synthesis of poly(ADP-ribose). Over 100 novel substrates of PARP-1 have been identified, most of which are involved in cellular processes such as ribosome biogenesis and transcription regulation. In addition, PARP-1 functions in inflammation by modulating inflammatory-relevant gene expression. PARP-1 also is involved in the tissue damage caused by ischemia/reperfusion conditions. Common inflammatory mediators (inducible nitric oxide synthase, interleukin [IL]-1β, and tumor necrosis factor-α) are regulated by PARP-1, which helps amplify nuclear factor-κB-mediated inflammation. PARP-1 plays a role in adaptive immunity by modulating the ability of dendritic cells to stimulate T cells. The expression of several genes (such as IL-2 and IL-10) and T-cell proliferation also are controlled by the activation of PARP-1. Inhibition of PARP-1 enzymatic activity attenuates the secretion of proinflammatory cytokines and therefore alleviates autoimmune diseases. PARP inhibitors may represent a new avenue for disease treatment.

CITADO POR
  1. Baldassarro Vito A., Marchesini Alessandra, Giardino Luciana, Calzà Laura, PARP activity and inhibition in fetal and adult oligodendrocyte precursor cells: Effect on cell survival and differentiation, Stem Cell Research, 22, 2017. Crossref

  2. Kim Choong-Gon, Lee Ji-Eun, Jeong Da-Geum, Lee Youn-Ho, Park Sang-In, Lee Dae-Geon, Han Chang-Hyun, Kang Su-Jin, Song Chang-Hyun, Choi Seong-Hun, Lee Young-Joon, Ku Sae-Kwang, Bathing effects of east saline groundwater concentrates on allergic (atopic) dermatitis-like skin lesions induced by 2,4-dinitrochlorobenzene in hairless mice, Experimental and Therapeutic Medicine, 13, 6, 2017. Crossref

  3. Malgras Mathilde, Garcia Magali, Jousselin Clément, Bodet Charles, Lévêque Nicolas, The Antiviral Activities of Poly-ADP-Ribose Polymerases, Viruses, 13, 4, 2021. Crossref

  4. Chang Cherry Yin-Yi, Chiang An-Jen, Yan Man-Ju, Lai Ming-Tsung, Su Yun-Yi, Huang Hsin-Yi, Chang Chan-Yu, Li Ya-Hui, Li Pei-Fen, Chen Chih-Mei, Hwang Tritium, Hogg Chloe, Greaves Erin, Sheu Jim Jinn-Chyuan, Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications, Biomedicines, 10, 1, 2022. Crossref

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