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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN En Línea: 2162-6502

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Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2019025723
pages 471-482

Stem Cell Therapy for Diabetes Mellitus: Recent Progress and Hurdles

Mohammad Saleem
Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan
Shakila Sabir
Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan; Department of Pharmacology, Government College University Faisalabad, Pakistan
Muhammad Furqan Akhtar
Faculty of Pharmacy, Government College University, Faisalabad, Pakistan; Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, Pakistan
Sara Zahid
Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan
Sammia Gul Niazi
Faculty of Pharmaceutical Sciences, Hamdard University, Islamabad, Pakistan
Muhammad Naeem
Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
Uzma Saleem
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
Ammara Saleem
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan


Diabetes mellitus (DM) is a devastating metabolic syndrome. Currently, parenteral exogenous insulin is the only therapy available around the world to treat type 1 DM. However, it does not tightly regulate blood glucose levels that ultimately lead to long-term complications. The development of pancreatic transplantation gives some hope in the radical cure of diabetes. A limited number of donors and host immune rejection are two major drawbacks associated with pancreatic transplantation. Stem cells are distinctive cells that can differentiate into any other type of specialized cells. Embryonic stem cells have been studied extensively and proved successful in producing beta cells. The numerous kinds of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells, prove to be among the notable candidates to treat DM. However, all stem cell therapies have their own limitations. This review article focuses on the progress and limitations in stem cell research to treat DM.


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