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Critical Reviews™ in Eukaryotic Gene Expression
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ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.30
pages 183-190

Interrelationships of Transcriptional Machinery with Nuclear Architecture

Gary S. Stein
Department of Biochemistry University of Vermont 149 Beaumont Ave., HSRF 326 Burlington, VT 05405
Andre J. van Wijnen
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655
Janet L. Stein
Department of Biochemistry University of Vermont 89 Beaumont Ave., Given E210E Burlington, VT 05405
Jane B. Lian
Department of Biochemistry University of Vermont 89 Beaumont Ave., Given E210B Burlington, VT 05405

SINOPSIS

There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.


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