Suscripción a Biblioteca: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Publicado 6 números por año

ISSN Imprimir: 1045-4403

ISSN En Línea: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Functional Genomics in Rat Models of Hypertension: Using Differential Expression and Congenic Strains to Identify and Evaluate Candidate Genes

Volumen 12, Edición 4, 2002, 20 pages
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i4.40
Get accessGet access

SINOPSIS

Hypertension is a leading contributor to cardiovascular diseases such as heart attack and stroke. Genetic and environmental factors contribute to the development of hypertension. Animal models have been developed to study the genetic contributions to blood pressure (BP) regulation and to identify chromosomal regions harboring candidate genes causative of differences in BP regulation (i.e., BP quantitative trait loci [QTL]). Advances in both mammalian genome projects and global gene expression analysis present opportunities to study functional genomics in these animal models. In this article, novel approaches for designing experiments and interpreting global gene expression data using the Dahl salt-sensitive hypertension rat model are presented. We describe two-step screening protocols that can be used to identify BP QTL candidate genes. Genetically determined expression differences are identified in the target organs of inbred strains of contrasting phenotype in the first screen. Expression patterns in a panel of congenic strains or expression differences stemming from gene x environment interactions are examined in the second screen. Chromosomal locations of these genes can then be examined to determine whether they map to BP QTL–containing regions. Another approach is to study the expression of genes identified from public databases to be located within BP QTL–containing congenic regions. Several candidate genes have been identified using these strategies.

CITADO POR
  1. Saavedra Juan M, Opportunities and limitations of genetic analysis of hypertensive rat strains, Journal of Hypertension, 27, 6, 2009. Crossref

  2. Toland Edward J., Saad Yasser, Yerga-Woolwine Shane, Ummel Steven, Farms Phyllis, Ramdath Ramona, Frank Bryan C., Lee Norman H., Joe Bina, Closely linked non-additive blood pressure quantitative trait loci, Mammalian Genome, 19, 3, 2008. Crossref

  3. Castaneda Carol, LaPointe Michael S., Gold Standard Animal Models, in Pharmaceutical Sciences Encyclopedia, 2011. Crossref

  4. Saad Yasser, Garrett Michael R., Manickavasagam Ezhilarasi, Yerga-Woolwine Shane, Farms Phyllis, Radecki Tracy, Joe Bina, Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10, Genomics, 89, 3, 2007. Crossref

  5. Ulfenborg Benjamin, Jurcevic Sanja, Lindlöf Angelica, Klinga-Levan Karin, Olsson Björn, miREC: a database of miRNAs involved in the development of endometrial cancer, BMC Research Notes, 8, 1, 2015. Crossref

  6. Sommer Stacy L., Berndt Theresa J., Frank Elena, Patel Jeetendra B., Redfield Margaret M., Dong Xiangyang, Griffin Matthew D., Grande Joseph P., van Deursen Jan M. A., Sieck Gary C., Romero Juan C., Kumar Rajiv, Elevated blood pressure and cardiac hypertrophy after ablation of thegly96/IEX-1gene, Journal of Applied Physiology, 100, 2, 2006. Crossref

  7. Lee Soon Jin, Ways Justin A., Barbato John C., Essig David, Pettee Krista, DeRaedt Sarah J., Yang Siming, Weaver David A., Koch Lauren G., Cicila George T., Gene expression profiling of the left ventricles in a rat model of intrinsic aerobic running capacity, Physiological Genomics, 23, 1, 2005. Crossref

  8. NARABA Hiroaki, IWAI Naoharu, Assessment of the MicroRNA System in Salt-Sensitive Hypertension, Hypertension Research, 28, 10, 2005. Crossref

  9. Garrett Michael R., Meng Haijin, Rapp John P., Joe Bina, Locating a Blood Pressure Quantitative Trait Locus Within 117 kb on the Rat Genome, Hypertension, 45, 3, 2005. Crossref

Próximos Artículos

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain