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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v1.i3.40
pages 227-234

Production of Immunoregulatory Cytokines at Autoimmune Damage of Mammalian Ovaries

Roman I. Yanchii
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana Yu. Voznesenska
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Olena A. Shepel
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana M. Bryzgina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vera S. Sukhina
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
L. M. Lazarenko
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Z. M. Olenivska
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
Mykola Ya. Spivak
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
R. M. Serbenjuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
O. M. Serdyuk
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv

SINOPSIS

Several ovarian disorders in women are associated with autoimmune factors. In this study it was investigated a level of cytokines − TNF-α and IFNs in ovarian homogenate and blood serum at ovarian autoimmune damage of mammals. Experimental immune ovarian failure was induced in CBA mice by either immunization with allogenic ovarian extracts or administration of xenogenic anti-ovarian antibodies. Both models were accompanied with abnormalities in production immunoregulatory cytokines. These data confirm importance of definition of proinflammatory cytokine level for disclosing immune mechanisms which lay in a pathogenesis autoimmune ovarian diseases of female reproductive organs.


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