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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

An Increased Ca2+ Sensitivity of Mitochondrial Permeability Transition Pore in Rat Hearts with Nigrostriatal Dopamine Chronic Deficiency

Volumen 1, Edición 3, 2010, pp. 219-226
DOI: 10.1615/IntJPhysPathophys.v1.i3.30
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SINOPSIS

We studied the sensitivity of mitochondrial permeability transition pore (MPTP) opening in response to natural inductor − Ca2+ ions in the rat heart mitochondria which chronic deficiency of nigostriatal dopamine caused by an injection of selective neurotoxin 6-xydroxidofamine in an ascending lateral bundle of the forebrain. MPTP-opening was determined spectrophotometrically (λ = 520 nm) by a decrease in an optical density resulting from mitochondria swelling. It has been shown that the rat heart mitochondria with chronic deficiency of nigrostriatal dopamine are more sensitive to Ca2+ in its physiological concentrations (10−7 M) and overload (10−6 − 10−4 M) in comparison to control animals. Thus, obtained results lead to a conclusion that an increased sensitivity of the mitochondrial permeability transition pore to calcium and mitochondrial membrane permeability may be one of the causes previously reported of disturbance in contractile function of the rat heart with chronic deficiency in nigrostriatal dopamine.

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