International Journal of Physiology and Pathophysiology
Publicado 4 números por año
ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158
SJR:
0.116
Electrical Properties of Retinal Ganglion Cells of the Rats with Streptozotocin-Induced Diabetes Mellitus
Volumen 5,
Edición 1, 2014,
pp. 57-63
DOI: 10.1615/IntJPhysPathophys.v5.i1.60
SINOPSIS
On isolated retinal preparation from rats with streptozotocin-induced diabetes mellitus in whole-cell configuration, basic electrical properties of retinal ganglion cells (RGC) were studied. It has been shown that on the 8th week after streptozotocin injection, maximal depolarization-induced firing frequency is reduced and decay time constant of high-frequency stimulation-induced calcium signals increases, compared with the values in control animals. The data obtained point at functional changes in RGC of streptozotocin-induced diabetic rats, and possible mechanisms of such changes are discussed.
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