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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i1.90
pages 77-83

Serum Testosterone Levels in Statin Therapy for Patients with Diabetes and Hypertension

Abdalla Mohammed Jarrari
Faculty of Medicine, Benghazi University, Benghazi, Libya
Shakila Srikumar
Faculty of Medicine, Quest International University Perak, IPOH, Malaysia
Wahid M. El Sheriff
Faculty of Medicine, Benghazi University, Benghazi, Libya
Noah Mohammed Hamed Aljarari
Faculty of Medicine, Benghazi University, Benghazi, Libya
Sara A. Shoaib
Faculty of Medicine, Benghazi University, Benghazi, Libya
Ahmed M. Zakoko
Faculty of Medicine, Benghazi University, Benghazi, Libya
Dawoodi Fakruddin
Faculty of Medicine, Quest International University Perak, IPOH, Malaysia
Mohammed G. Elfturi
Faculty of Medicine, Benghazi University, Benghazi, Libya
Aaren Vedangi
Triesta Sciences, HCG Pinnacle Oncology Pvt. Ltd, Visakhapatnam, India
Anuradha Argi
Department of Human Genetics, College of Science and Technology, Andhra University, Visakhapatnam, India
Avinash K. Rawal
St. Matthew's University School of Medicine, Cayman Islands
Yupa Min
Faculty of Medicine, Quest International University Perak, IPOH, Malaysia
Azhar Hussain
Davenport University College of Health Professionals
Laxmi Teja Peela
Queen's NRI Hospital, Visakhapatnam, India
Jagannadha Rao Peela
St. Matthew's University School of Medicine.Grand Cayman, Cayman Islands

SINOPSIS

Hypogonadism in males is a state that needs therapeutic attention and intervention considering that it is associated with aging, diabetes mellitus, and statin therapy. The study was carried out to determine the levels of serum testosterone in subjects treated with statins. Subjects undergoing statin therapy were grouped into two categories: those receiving statins for less than one year and those treated with statins for more than one year. The average age of subjects was (45 ± 8.5.) Subjects with low-density lipoprotein (LDL) cholesterol amount in the blood serum higher than 190mg/dL were included in a group of hypercholesterolemic adults. They received statins (atorvastatin, 40mg/day). Diabetic patients were either diagnosed according to appropriate criteria or those who were already on medications. Electrochemiluminescence immunoassay (ECLIA) for the in vitro quantitative determination of testosterone in human serum and plasma with a Cobas e411 analyzer were used. It has been shown that serum testosterone level in subjects that received statins was significantly reduced compared to that in control subjects, as well as in diabetic ones. The level of serum testosterone did not depend on the presence of hypertension or diabetes combined with hypertension.