Publicado 4 números por año
ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158
Role of HIF-1 in Neuronal Mechanisms of Adaptation to Psychoemotional and Hypoxic Stress
SINOPSIS
Using quantitative immunohistochemistry, neuronal expression of α-subunit of the transcriptional factor HIF-1 was studied in the hippocampus and the neocortex of rats in response to pathogenic psychoemotional stress (model of posttraumatic stress disorder, PTSD) and hypoxic stress (severe hypobaric hypoxia, 180 mm Hg, 3 h), as well as following neuroprotective hypoxic pre- and postconditioning. Prolonged overexpression of HIF-1 α in the hippocampus and the neocortex of rats in response to the psychoemotional stress in PTSD paradigm, but not hypoxic stress, has been observed. Hypoxic pre- and postconditioning with mild hypobaric hypoxia (360 Torr, 2 h, 3 trials spaced at 24 h), which promotes adaptation to the psychoemotional stress, was shown to abolish the prolonged HIF-1 α overexpression. In addition, hypoxic postconditioning up-regulated HIF-1α expression in the brain neurons of rats survived severe hypoxia by improving the structure and functional rehabilitation after severe hypoxic stress. The results obtained indicate that a transcription factor HIF-1 is particularly involved in the processes of adaptation/maladaptation to the action of injurious stresses, but its role depends upon the nature of a stressor.
-
Rybnikova Elena, Samoilov Mikhail, Current insights into the molecular mechanisms of hypoxic pre- and postconditioning using hypobaric hypoxia, Frontiers in Neuroscience, 9, 2015. Crossref
-
Vetrovoy Oleg, Sarieva Kseniia, Galkina Olga, Eschenko Natalia, Lyanguzov Andrey, Gluschenko Tatjana, Tyulkova Ekaterina, Rybnikova Elena, Neuroprotective Mechanism of Hypoxic Post-conditioning Involves HIF1-Associated Regulation of the Pentose Phosphate Pathway in Rat Brain, Neurochemical Research, 44, 6, 2019. Crossref
-
Sarieva K. V., Lyanguzov A. Yu., Galkina O. V., Vetrovoy O. V., The Effect of Severe Hypoxia on HIF1- and Nrf2-Mediated Mechanisms of Antioxidant Defense in the Rat Neocortex, Neurochemical Journal, 13, 2, 2019. Crossref
-
Vetrovoy Oleg, Rybnikova Elena, Neuroprotective action of PHD inhibitors is predominantly HIF‐1‐independent, Journal of Neurochemistry, 150, 6, 2019. Crossref
-
Rybnikova Elena A., Nalivaeva Natalia N., Zenko Mikhail Y., Baranova Ksenia A., Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain, Frontiers in Neuroscience, 16, 2022. Crossref