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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Changes in Tripeptidyl Peptidase II Activity in Aortic Tissues under Experimental Atherosclerosis and Arterial Hypertension

Volumen 6, Edición 2, 2015, pp. 151-156
DOI: 10.1615/IntJPhysPathophys.v6.i2.70
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SINOPSIS

Changes in the activity of intracellular proteolytic systems are important mechanisms of atherosclerotic damage to the vascular wall and arterial hypertension. Tripeptidyl peptidase II (TPP II) is a poorly known giant intracellular protease which assures hydrolysis of peptides formed via proteasomal proteolysis. The significant decrease in TPP II activity in aorta tissues has been revealed in rabbits with experimental cholesterol atherosclerosis (1% dietary cholesterol for 2 months). In spontaneously hypertensive rats (SHR), cholesterol diet also led to a decrease in TPP II activity in aorta tissues (by 50%, P < 0.05), but the latter was unchanged in Wistar rats. Application of Quercetin prevented the inhibition of TPP II activity in aorta tissues of rabbits and SHR in experimental hypercholesterolemia. The data obtained indicate that changes in the TPP II activity lead to the vascular wall damage under atherosclerosis and arterial hypertension.

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