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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v2.i4.80
pages 361-370

Effects of Chronic Stress during Puberty on Reproductive System of Female Rats with Experimental Hyperandrogenicity

Nadiya D. Nosenko
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
I. Yu. Ganzhiy
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine;Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine
Pyotr V Sinitsyn
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine
L. I. Polyakova
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Larisa V. Tarasenko
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine; Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine
Anna A. Lymareva
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine;Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine
L. V. Chaikovskaya
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Alexander G. Reznikov
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

SINOPSIS

We studied effects of chronic stress (30-minute daily immobilization) from the 35-th to 45-th day of life and its combination with androgenization (implantation of testosterone-containing capsules on the 33-th day of life) on the reproductive system of 2.5 month old female rats. The terms of sexual maturation, estrous cycle regularity and structure, blood plasma levels of testosterone, progesterone and androstenedione, as well as ovarian histology were examined. Androgenization resulted in increased level of testosterone in blood plasma and decreased level of androstenedione, development of oligo- or anovulatory state, which is characterized by disorders or discontinuation in estrous cyclicity, abrupt reduction or absence of post ovulary luteal bodies, cysts formation and ovarian interstitial tissue overgrowth. All experimental animals had normal corticosterone level in blood plasma. Except for certain violations of the regularity of the estrous cycle, exposure to stress in rats did not cause significant changes in the reproductive system, and together with androgenization it delayed pubescence, increased the number of ovarian cysts along with attenuation of androgenization-caused negative effects on the sexual cyclicity.


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