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International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Matrix Gla-Protein Gene Polymorphism in Patients with Ischemic Atherothrombotic Stroke

Volumen 4, Edición 2, 2013, pp. 103-112
DOI: 10.1615/IntJPhysPathophys.v4.i2.30
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SINOPSIS

Matrix Gla-protein (MGP) gene allelic polymorphism was determined in 170 patients with ischemic atherothrombotic stroke (IATS) and in 124 healthy subjects (control group). It has been shown that in patients with IATS the ratio of main homozygotes, heterozygotes and minor homozygotes is 61.2, 31.2, and 7.6%, respectively, when analyzing T−138 → C (rs1800802) promoter polymorphism (in the control group, it is 59.7, 35.6, and 4.8%, P = 0.521 by χ2-test); it is 35.9, 48.8, and 15.3% for G−7 → A (rs1800801) promotor polymorphism (in the controlgroup, it is 43.5, 50.0, and 6.5%, P = 0.051); and it is 39.4, 48.8, and 11.8% for Thr83 → Ala (rs4236) polymorphism of the 4th exon (in control group, it is 34.7, 53.2, and 12.1%, P = 0.701). Significant difference in the frequency of G−7 → A polymorphism between the patients with IATS and the control group were revealed only for women (P = 0.022). The results obtained suggest that the A/A-variations of MGP gene promotor (G−7 → A polymorphism) is associated with an increased risk of IATS in females in Ukrainian population.

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