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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i4.70
pages 341-348

Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation

Kateryna V. Yatsenko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine; "Neurological clinic of doctor Yatsenko", Kyiv, Ukraine


The effect of combined treatment with transcranial direct current stimulation (tDCS) on cerebral blood flow in patients with symptomatic epilepsy was studied. 29 patients with symptomatic epilepsy were examined and received the course of treatment. The comparison group was formed from 14 children who received the course of basic medical and rehabilitation procedures. The main group included 15 children who, in addition to the same therapy, received a course of tDCS. A transcranial Doppler ultrasound examination of cerebral blood vessels was used to evaluate cerebral hemodynamics in children with symptomatic epilepsy before and after combined treatment with tDCS. After the course of tDCS, the children had a marked improvement in the EEG pattern, and also tDCS significantly reduced the high mean blood flow rate per cycle in the basilar, middle, and anterior cerebral arteries (20.5, 17.2, and 7.9%, respectively). In the comparison group, no statistically significant positive dynamics was observed. tDCS significantly increased the low mean blood flow rate in the basilar, middle, and anterior cerebral arteries (by 25.1, 20.9, and 10.2%, respectively); a statistically significant increase in MVF by 12.7% was observed only in the middle cerebral artery in the comparison group of patients. Our data indicate that the use of tDCS in the combined treatment of patients with epilepsy improves cerebral hemodynamics in 84% of patients, in contrast to 58% in the comparison group. Including the method of tDCS to the complex treatment of patients with epilepsy improves the effectiveness of treatment and may also positively influence the clinical course of the disease.

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