Publicado 4 números por año
ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158
Effect of Chronic Postnatal Stress on Pro-and Antioxidant System and Changes in Autonomic Balance of Cardiac Rhythm in Rats
SINOPSIS
The effect of chronic postnatal stress on changes in autonomic regulation of cardiac rhythm, the state of the pro- and antioxidant system in 20 male white outbred rats and 24 females at the sexually mature age of 3 months was studied. It has been found that chronic postnatal stress in male rates results in a compensatory decrease in the regulatory influence of the sympathetic part of the autonomic nervous system on the sinoatrial node of the heart (the moda increased by 12.2%), it also changes automatism (heart rate decreased by 14.9%) and conductivity (duration of PQ and Q-T intervals increased by 30.24% and 7.78%, respectively). In female rats, an increase in ventricular repolarization was observed (T wave amplitude increased by 39.4%). In the heart of the rats of both sexes exposed to stress, the processes of lipid peroxidation were intensified, and the enzyme activity of the antioxidant system increased, more significantly in male rats (superoxide dismutase and catalase activities increased 18 times, and 2.9 times, respectively), as well as enzyme link of antioxidant system (the content of ceruloplasmin and peroxidase activity in the blood increased 1.5 times and 15.9 times, respectively). Consequently, chronic postnatal stress causes changes in autonomic regulation of cardiac rhythm, pro- and antioxidant systems which are more pronounced in male rats.