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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimir: 2155-014X
ISSN En Línea: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i4.50
pages 331-339

Bioelectric Activity of the Spinal Cord Interneurons in Experimental Menopause in Female Rats

Oleksandr G. Rodinsky
Dnipropetrovsk Medical Academy, Health Ministry of Ukraine, Dnipropetrovsk, Ukraine
Sergey S. Tkachenko
Dnipropetrovsk Medical Academy, Ministry of Health of Ukraine, Dnipropetrovsk, Ukraine


We analyzed the features of the amplitude-time characteristics of the spinal cord dorsal surface potentials (PDS) in adult male rats under experimental menopause. It has been found that the threshold for excitation and the latent period increased by 102.14% and 94.12%, respectively, in animals with experimental menopause. Under supramaximum stimulation of the L5 dorsal root, amplitudes of N1-, N2-, and N3-components increased by 10.14%, 11.82%, and 48.28%, respectively, P-wave increased by 31.58%, and duration of N3-component increased by 26.54% in the experimental group. Stimulation by paired pulses at time intervals from 2 to 3 ms resulted in a significant increase in Ni-component (P < 0.01), whereas at time interval from 6 to 30 ms, we observed the inhibition of N1-component of another PDS in the group of animals with experimental menopause. Thus, our results suggest the presence of differently directed changes in excitability of the posterior horn nervous structures of the spinal cord under estrogen deficiency.