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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i5.30
pages 459-466

Antimalarial and Hepatoprotective Effects of Crude Ethanolic Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.)P.Karst. (Higher Basidiomycetes), in Plasmodium berghei-Infected Mice

Olarewaju M. Oluba
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria; Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria
Augustine O. Olusola
Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba Akoko, Nigeria
Bamidele S. Fagbohunka
Department of Chemical Sciences, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji-Arakeji, Osun State, Nigeria
E. Chukwu Onyeneke
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin-City, Nigeria

SINOPSIS

This study was aimed at investigating the in vivo antimalarial activity (using some biochemical indices) of crude aqueous extracts of the fruiting bodies of Ganoderma lucidum, a mushroom with well-established medicinal properties. A rodent malaria parasite, Plasmodium berghei (1 × 107), was inoculated intraperitoneally into Swiss albino mice. The test groups were administered G. lucidum extract and chloroquine (CQ, as standard drug), while the control groups were administered the same amount of distilled water by an intragastric tube once daily. The antimalarial activity of the extract was investigated from the suppressive, curative, and prophylactic effects of the extract on parasite growth. Serum aminotransferases (AST and ALT), alkaline phosphatase (ALP), and gamma glutamine transpeptidase (γ-GT) levels monitored following the 4-day suppressive test were significantly reduced, with a corresponding significant increase in the livers of mice treated with the extract compared with infected untreated mice. The results obtained from this study provide scientific justification in an animal model of malaria that an ethanolic extract of G. lucidum possesses potent antimalarial activity and also could help ameliorate the attendant Plasmodium-induced liver damage due to malarial infection.


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