Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i5.90
pages 507-512

Teratogenic and Toxic Effects of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Higher Basidiomycetes), on Zebrafish Embryo as Model

Rich Milton R. Dulay
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines
Sofronio P. Kalaw
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines ;Department of Biological Sciences, College of Arts and Sciences, Central Luzon State University, Science City of Munoz
Renato G. Reyes
Center for Tropical Mushroom Research and Development, Central Luzon State University, Science City of Munoz, Nueva Ecija, Philippines;Department of Biological Sciences, College of Arts and Sciences, Central Luzon State University, Science City of Munoz,
Noel F. Alfonso
Department of Biology, College of Sciences, De La Salle University, Taft Avenue, Manila, Philippines
Fumio Eguchi
Laboratory of Forest Products Chemistry, Department of Forest Science, Faculty of Regional Environment Science, Tokyo University of Agriculture, 1-1-1, Sakuragaoka, Setagayaku, Tokyo, Japan

SINOPSIS

This paper highlights the teratogenic and toxic effects of Ganoderma lucidum (Lingzhi or Reishi mushroom) extract on zebrafish embryos. Hatchability, malformations, and lethality rate of zebrafish embryos were assessed to provide valuable information regarding the potential teratogenic activity of G. lucidum. Hatching was completed 48 h post treatment application (hpta) at 1% or lower concentrations of extract and embryo water. The hatching rate of embryos treated with 5% or higher concentrations was significantly lower (p> 0.05) than the control. Tail malformation was the most marked morphological abnormality in embryos at 72 hpta, which was obviously caused by 1% extract (55.56% tail malformation) and was observed in all embryos exposed to 5% of extract. Growth retardation was evident in embryos exposed to 5%, 10%, and 20%. However, lethal effect of extract of G. lucidum was dependent on dose and time of exposure. Mortality rates of embryos treated with 5% (44.44%) or higher concentrations of the extract was significantly higher (p > 0.05) than that of the control embryos at 72 hpta. These results suggest that G. lucidum extract has lethal and sub-lethal effects on zebrafish embryos.


Articles with similar content:

Skin Mucus Protein Profile, Immune Parameters, Immune-Related Gene Expression, and Growth Performance of Rainbow Trout (Oncorhynchus mykiss) Fed White Button Mushroom (Agaricus bisporus) Powder
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 4
Roghieh Safari, Seyed Hossein Hoseinifar, Omid Amiri, Hamed Kolangi Miandare, Ali Shabni
DNA Damage in Wistar Rats Exposed to Organophosphate Pesticide Fenthion
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 4
Cláudia Regina Klauck, Luciano Basso da Silva, Julia Puffal, Patricia Grolli Ardenghi, Angélica Goldoni
Antitumor Activity of Oral Administration of Mycovirus Extract from Lentinus edodes (Berk.) Sing. (Agaricomycetideae) on Murine Lymphoma
International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 2
Mah-Lee Ng, Sudhir C. Kumar
The Optimum Submerged Culture Condition of the Culinary-Medicinal White Jelly Mushroom (Tremellomycetes) and Its Antioxidant Properties
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 3
Yang-Chia Shih, Chien-Yih Lin, Jessica Krisanti Gusman
Zoledronic Acid Aggravates Kidney Damage During Ischemia Reperfusion Injury in Rat
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 1
Orhan Unal Zorba, Levent Tumkaya, Ahmet Fikret Yucel, Ibrahim Sehitoglu, Medine Cumhur Cure, Erkan Cure, Suleyman Yuce, Recep Bedir, Yildiray Kalkan