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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018025329
pages 13-29

Antiproliferative and Antioxidant Activities of Wild Boletales Mushrooms from France

Sylvie Morel
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Stéphanie Arnould
Institut de Recherche en Cancérologie de Montpellier, U1194 INSERM/Université de Montpellier/ICM, Montpellier, France
Manon Vitou
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Frédéric Boudard
Laboratoire d'Immunologie, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Caroline Guzman
Laboratoire d'Immunologie, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Patrick Poucheret
Laboratoire de Pharmacologie and Physiopathologie Expérimentale, Faculté de Pharmacie, UMR 95 Qualisud CIRAD Université de Montpellier, Montpellier, France
Françoise Fons
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France
Sylvie Rapior
Laboratoire de Botanique, Phytochimie et Mycologie, Faculté de Pharmacie, CEFE UMR 5175 CNRS Université de Montpellier Université Paul-Valéry Montpellier EPHE, Montpellier, France

SINOPSIS

We selected edible and inedible mushrooms growing in the Mediterranean area of France to screen their biological activity: Caloboletus calopus, Rubroboletus lupinus, R. pulchrotinctus, R. satanas, Gyroporus castaneus, Suillus luteus, and Omphalotus olearius. Mushrooms were sequentially extracted using cyclohexane, chloroform, ethanol, and water. The antiproliferative activity against the HCT116 colon adenocarcinoma cell line and the antioxidant properties (DPPH radical scavenging assay, Folin-Ciocalteu assay, and oxygen radical absorbance capacity) of the Boletales extracts were evaluated and compared. Among the 28 mushroom extracts evaluated, 11 presented antiproliferative activity against HCT116 cells. These activities were not linked to antioxidant capacity. Among the antioxidant extracts, most were aqueous extracts in the oxygen radical absorbance capacity assay, whereas the highest values on the Folin-Ciocalteu and DPPH assays were noted for chloroform, ethanol, or aqueous extracts, depending on the mushroom species. Further studies are necessary to identify bioactive compounds and to valorize the mushrooms−for edible species, directly as health foods, or, for inedible mushrooms, as ingredients in the pharmaceutical and food industries.


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