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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages

Volumen 17, Edición 7, 2015, pp. 609-618
DOI: 10.1615/IntJMedMushrooms.v17.i7.10
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SINOPSIS

Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation. The anti-inflammatory effects of the ethyl acetate soluble fraction of H. erinaceus (EAHE) were examined using cocultures of 3T3-L1 adipocytes and RAW264 macrophages. EAHE significantly suppressed tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in cultured RAW264 macrophages stimulated by lipopolysaccharide (LPS). EAHE also caused notable inhibition of c-Jun N-terminal kinase (JNK) activation, which is thought to be involved in the suppression of proinflammatory cytokines by EAHE. In a coculture system with 3T3-L1 and RAW264 cells stimulated with LPS, EAHE reduced TNF-α and IL-6 concentrations in the conditioned medium and lowered the gene expression levels of these cytokines in 3T3-L1 adipocytes. Furthermore, EAHE suppressed the LPS-induced reduction of adiponectin mRNA levels in 3T3-L1 adipocytes cocultured with RAW264 macrophages. However, in 3T3-L1 adipocytes cultured alone, the concentration of LPS used in this study did not affect the gene expression levels of these adipokines. We attributed the anti-inflammatory effects of EAHE on 3T3-L1 adipocytes cocultured with RAW264 macrophages to the suppression of Toll-like receptor 4 (TLR4) signaling and subsequent proinflammatory cytokine secretion in RAW264 cells. Our findings indicate the possibility that H. erinaceus exerts anti-inflammatory effects on macrophages through the inhibition of TLR4-JNK signaling and prevents or ameliorates adipose tissue inflammation associated with obesity.

CITADO POR
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  3. Kushairi , Phan , Sabaratnam , David , Naidu , Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia, Antioxidants, 8, 8, 2019. Crossref

  4. Zhao Shuang, Zhang Shuman, Zhang Weiwei, Gao Yi, Rong Chengbo, Wang Hexiang, Liu Yu, Wong Jack Ho, Ng Tzibun, First demonstration of protective effects of purified mushroom polysaccharide-peptides against fatty liver injury and the mechanisms involved, Scientific Reports, 9, 1, 2019. Crossref

  5. Zhang Mengdi, Xie Yu, Su Xing, Liu Kun, Zhang Yijie, Pang Wuyan, Wang Junpeng, Inonotus sanghuang Polyphenols Attenuate Inflammatory Response Via Modulating the Crosstalk Between Macrophages and Adipocytes, Frontiers in Immunology, 10, 2019. Crossref

  6. Atila Funda, Fenolik İçeriği Yüksek Tarımsal Atıkların Hericium erinaceus ve Lentinula edodes Mantarlarının Üretiminde Kullanımı, Ege Üniversitesi Ziraat Fakültesi Dergisi, 2019. Crossref

  7. Wang Li-Yu, Huang Chin-Shiu, Chen Yu-Hsuan, Chen Chin-Chu, Chen Chien-Chih, Chuang Cheng-Hung, Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS, Molecules, 24, 18, 2019. Crossref

  8. Chong Pit Shan, Fung Man-Lung, Wong Kah Hui, Lim Lee Wei, Therapeutic Potential of Hericium erinaceus for Depressive Disorder, International Journal of Molecular Sciences, 21, 1, 2019. Crossref

  9. Yang Pao-Pao, Chueh Sheau-Huei, Shie Hua-Lun, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Chen Yu-Wen, Shiu Li-yen, Liu Pei-Shan, Effects of Hericium erinaceus Mycelium Extracts on the Functional Activity of Purinoceptors and Neuropathic Pain in Mice with L5 Spinal Nerve Ligation, Evidence-Based Complementary and Alternative Medicine, 2020, 2020. Crossref

  10. Chong Pit Shan, Poon Chi Him, Roy Jaydeep, Tsui Ka Chun, Lew Sze Yuen, Phang Michael Weng Lok, Tan Rachael Julia Yuenyinn, Cheng Poh Guat, Fung Man-Lung, Wong Kah Hui, Lim Lee Wei, Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression, Chinese Medicine, 16, 1, 2021. Crossref

  11. Kim Jin-Nam, Han Sung Nim, Kim Hye-Kyeong, Anti-Inflammatory and Anti-Diabetic Effect of Black Soybean Anthocyanins: Data from a Dual Cooperative Cellular System, Molecules, 26, 11, 2021. Crossref

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  13. Dimopoulou Maria, Kolonas Alexandros, Mourtakos Stamatis, Androutsos Odysseas, Gortzi Olga, Nutritional Composition and Biological Properties of Sixteen Edible Mushroom Species, Applied Sciences, 12, 16, 2022. Crossref

  14. Cho Hyun-Woo, Choi Soyoung, Seo Kangmin, Kim Ki Hyun, Jeon Jung-Hwan, Kim Chan Ho, Lim Sejin, Jeong Sohee, Chun Ju Lan, Gut microbiota profiling in aged dogs after feeding pet food contained Hericium erinaceus, Journal of Animal Science and Technology, 64, 5, 2022. Crossref

  15. Tada Hiroyuki, Kawahara Kazuyoshi, Osawa Hiraku, Song Li-Ting, Numazaki Kento, Kawai Junya, Onoue Sakura, Nishioka Takashi, Nemoto Eiji, Matsushita Kenji, Sugawara Shunji, Hericium erinaceus ethanol extract and ergosterol exert anti-inflammatory activities by neutralizing lipopolysaccharide-induced pro-inflammatory cytokine production in human monocytes, Biochemical and Biophysical Research Communications, 636, 2022. Crossref

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