Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v10.i3.60
pages 255-264

Antiproliferative Effects of Sclerotial Polysaccharides from Polyporus rhinocerus Cooke (Aphyllophoromycetideae) on Different Kinds of Leukemic Cells

Connie K. M. Lai
Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
Ka-Hing Wong
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong, China
Peter Chi Keung Cheung
Department of Biology, The Chinese University of Hong Kong Shatin, New Territories, Hong Kong, SAR of PRC

SINOPSIS

Mushroom polysaccharides isolated from fruiting bodies are known for their antitumor activities, whereas those from mushroom sclerotia are not. A hot water- (PR-HW) and a cold alkaline (PR-CA)-soluble polysaccharide isolated from a novel mushroom sclerotium, Polyporus rhinocerus Cooke, were characterized to be a polysaccharide-protein complex and a glucan, respectively. Their in vitro antitumor activities against different leukemic cell lines were investigated. PR-HW demonstrated significant growth inhibition of human acute promyelocytic leukemic cells (HL-60), chronic myelogenous leukemia cells (K562), and human acute monocytic leukemia cells (THP-1) in vitro, whereas PR-CA showed no such inhibition. Flow cytometric analysis has shown that the antiproliferative effect of PR-HW on HL-60 was mediated by cell cycle arrest at the G1 phase, which subsequently led to apoptosis. This suggests that structural differences in PR-HW and PR-CA greatly affects their antitumor activities.


Articles with similar content:

Cytotoxic Activities of Fractions of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), and the Induction of Cell Cycle Arrest and Apoptosis in MGC-803 Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 6
Fei-Fei Wang, Wei Ma, Ning Li , Feng Liu, Chao Shi, Kai-Jin Wang
Anti-inflammatory Activity of Mycelial Extracts from Medicinal Mushrooms
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Hong-Yu Xu, Zhenming Lu, Yan Geng, Zheng-Hong Xu, Jin-Song Shi, Shuiling Zhu
A Comparison Study of the Anticancerous Activity and Mechanism of Ethanolic Extracts from Different Ganoderma lucidum (W.Curt.:Fr.) Lloyd Strains
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Yang Qing-Yao, Mi Ke, Feng Hui-Qing, Zhou Yue-Qing, Xiao-Tong Yang, Xu-Quan Li
Bacillus thuringiensis Parasporal Proteins Induce Cell-Cycle Arrest and Caspase-Dependant Apoptotic Cell Death in Leukemic Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Vishna Devi Nadarajah, Rebecca Shin-Yee Wong, Tengku Azmi Tengku Ibrahim, KoK-Keong Chan, Shar Mariam Mohamed, Maha Abdullah
GC-MS Analysis and Cytotoxicity Detection of Volatile Oil from the Fragrant Bracket Mushroom, Trametes suaveolens (Agaricomycetes)
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 4
Yu Han, Haiying Bao, Tolgor Bau, Yu Li, Lie Ma