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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Effect of Hispolon from Phellinus lonicerinus (Agaricomycetes) on Estrogen Receptors, Aromatase, and Cyclooxygenase II in MCF-7 Breast Cancer Cells

Volumen 19, Edición 3, 2017, pp. 233-242
DOI: 10.1615/IntJMedMushrooms.v19.i3.50
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SINOPSIS

Phytoestrogen has previously been proposed as an alternative to hormone replacement therapy. Hispolon has been found to have phytoestrogenic properties. However, the possible effects of hispolon on estrogen receptors and other related molecules remain to be determined. This study was performed mainly to confirm the estrogenic function of hispolon as it relates to estrogen receptors, aromatase, and cyclooxygenase 2 (COX-2). Hispolon was shown to increase the serum 17β-estradiol in vivo. Immunohistochemical staining methods showed that hispolon exhibited a biphasic effect on ERα/β and aromatase expression in MCF-7 cells. Hispolon could also significantly inhibit aromatase activity, assessed using the enzyme-linked immunosorbent assay. Western blotting showed that COX-2 and aromatase could be inhibited by hispolon. These results further prove the phytoestrogenic features of hispolon and explore some pharmacological mechanisms that suggest that hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.

CITADO POR
  1. Sarfraz Ayesha, Rasul Azhar, Sarfraz Iqra, Shah Muhammad Ajmal, Hussain Ghulam, Shafiq Nusrat, Masood Muqaddas, Adem Şevki, Sarker Satyajit D., Li Xiaomeng, Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways, Environmental Research, 190, 2020. Crossref

  2. Islam Muhammad T., Ali Eunus S., Khan Ishaq N., Shaw Subrata, Uddin Shaikh Jamal, Rouf Razina, Dev Shrabanti, Saravi Seyed S.S., Das Niranjan, Tripathi Swati, Yele Santosh U., Das Asish K., Shilpi Jamil A., Mishra Siddhartha K., Mubarak Mohammad S., Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon, Anti-Cancer Agents in Medicinal Chemistry, 20, 14, 2020. Crossref

  3. Zhao Yanxia, Zheng Weifa, Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus, Journal of Ethnopharmacology, 265, 2021. Crossref

  4. Das Somenath, Prakash Bhanu, Edible mushrooms: Nutritional composition and medicinal benefits for improvement in quality life, in Research and Technological Advances in Food Science, 2022. Crossref

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