Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2017024413
pages 879-892

Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity

Alicia Gil-Ramirez
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain
Fhernanda R. Smiderle
Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
Diego Morales
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain
Coen Govers
Food & Biobased Research, Wageningen University and Research Centre, Wageningen, The Netherlands
Andriy Synytsya
Department of Carbohydrates and Cereals, Institute of Chemical Technology, Prague, Czech Republic
Harry J. Wichers
Food & Biobased Research, Wageningen University and Research Centre, Wageningen, The Netherlands
Marcello Iacomini
Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, Parana, Brazil
Cristina Soler-Rivas
Department of Production and Characterization of Novel Foods, CIAL–Research Institute in Food Science, Universidad Autónoma de Madrid, Madrid, Spain

SINOPSIS

Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(11→3),(11→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.