Publicado 12 números por año
ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
The Agaricoglyceride of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Higher Basidiomycetes) is Anti-Inflammatory and Reverses Diabetic Glycemia in the Liver of Mice
Get access
SINOPSIS
The agaricoglyceride is a new fungal secondary metabolite that constitutes esters of chlorinated 4-hydroxy benzoic acid and glycerol. The objective of this study was to explore whether the administration of agaricoglyceride could correct hepatic glycemic metabolism dysfunction by attenuating inflammation in the liver. The effects of agaricoglycerides on tumor necrosis factor-α, interleukin-1β, vascular endothelial growth factor-α, interleukin-17, insulin secretion, adiponectin, leptin, hepatic glycogen, nuclear factor-κB activation, and total antioxidant activity were studied respectively. We demonstrated that administration of agaricoglycerides alleviated glycemic metabolism dysfunction, inflammation, and oxidative stress in mice. These data indicate that agaricoglyceride supplementation could restrain metabolic dysfunction through suppressing the nuclear factor-κB pathway as well as decreasing the levels of inflammatory cytokines and total antioxidant activities.
-
Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref
-
Friedman Mendel, Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans, Foods, 5, 4, 2016. Crossref
-
Das Banani, De Biplab, Chetree Rishiraj, Mandal Subhash C., Medicinal Aspect of Mushrooms: A View Point, in Herbal Medicine in India, 2020. Crossref
-
Turło Jadwiga, The biotechnology of higher fungi - current state and perspectives, Folia Biologica et Oecologica, 10, 2014. Crossref
-
Wei Qi, Li Jie, Zhan Yishu, Zhong Qiangui, Xie Baogui, Chen Lei, Chen Bingzhi, Jiang Yuji, Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats , Food Science & Nutrition, 8, 2, 2020. Crossref
-
Anusiya G, Gowthama Prabu U, Yamini N V, Sivarajasekar N, Rambabu K, Bharath G, Banat Fawzi, A review of the therapeutic and biological effects of edible and wild mushrooms, Bioengineered, 12, 2, 2021. Crossref