Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i5.10
pages 401-426

Medicinal Mushrooms for Glycemic Control in Diabetes Mellitus: History, Current Status, Future Perspectives, and Unsolved Problems (Review)

Hui-Chen Lo
Department of Natural Sciences, Fu Jen Catholic University, #510, JhongZheng Rd., Xinzhuang District, New Taipei City, 24205, Taiwan, ROC
Solomon P. Wasser
International Centre for Biotechnology and Biodiversity of Fungi Institute of Evolution and Faculty of Natural Sciences University of Haifa, Mt. Carmel, Haifa 31905, Israel


Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia with defects in insulin secretion and/or insulin resistance. Despite great efforts that have been made in the understanding and management of diabetes, its prevalence continues to grow. Recent discoveries have opened up an exciting opportunity for developing new types of therapeutics from medicinal mushrooms to control DM and its complications. To date, more and more active components including polysaccharides and their protein complexes, dietary fibers, and other compounds extracted from fruiting bodies, cultured mycelium, or cultured broth of medicinal mushrooms have been reported as to having anti-hyperglycemic activity. These compounds exhibit their antidiabetic activity via different mechanisms. This article presents an overview of the multiple aspects of diabetes mellitus and the efficacy and mechanism of medicinal mushrooms for glucose control in diabetes, including the inhibition of glucose absorption, protection of beta-cell damage, increase of insulin release, enhancement of antioxidant defense, attenuation of inflammation, modulation of carbohydrate metabolism pathway, and regulation of insulin-dependent and insulin-independent signaling pathways. However, there is insufficient evidence to draw definitive conclusions about the efficacy of individual medicinal mushrooms for diabetes. In addition, the wide variability, the lack of standards for production, and the lack of testing protocols to assess product quality are still problems in producing medicinal mushroom products. Moreover, well-designed randomized controlled trials with long-term consumption are needed to guarantee the bioactivity and safety of medicinal mushroom products for diabetic patients.

Articles with similar content:

Multitargeted Treatment of Cancer Cachexia
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 3
Clelia Madeddu, Giovanni Mantovani, Antonio Maccio
Stem Cell Therapy for Diabetes Mellitus: Recent Progress and Hurdles
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 5
Ammara Saleem, Uzma Saleem, Mohammad Saleem, Muhammad Furqan Akhtar, Sara Zahid, Sammia Gul Niazi, Shakila Sabir, Muhammad Naeem
Mechanisms Behind the Anti-inflammatory Actions of Insulin
Critical Reviews™ in Immunology, Vol.31, 2011, issue 4
Morley D. Hollenberg, Eric Hyun, Rithwik Ramachandran, Nathalie Vergnolle
Studies of the Antimicrobial Activity of Mushrooms (Agaricales) from South America (Review)
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 11
Roberta Paulert, Marina Giombelli Rosenberger, Vagner G. Cortez
Nutrition and Diabetes Mellitus: How are They Interlinked?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 4
Muhammad Sajid Hamid Akash, Kanwal Rehman