Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2020034776
pages 467-478

Influence of Nigerian Jelly Ear Culinary−Medicinal Mushroom, Auricularia auricula-judae (Agaricomycetes), on Humoral and Cellular Immunity

Veronica Ibe
Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Awka, Nigeria
Stella Amarachi Ihim
Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria
Moses Ikegbunam
Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Awka, Nigeria
Malachy Ugwu
Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, Awka, Nigeria
Chukwuemeka Sylvester Nworu
Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria

SINOPSIS

The fruiting body of Auricularia auricula-judae has received attention in folk medicine due to its possible medicinal values. Therefore, this study evaluated the immunomodulatory effects of the hot aqueous extract (AAAJ) and the β-D-glucan-rich polysaccharide fraction of A. auricula-judae (BGPA) on specific and nonspecific humoral and cell mediated immune responses in immunocompetent and immunosuppressed mice. Oral supplementation with AAAJ or BGPA (100, 200, or 400 mg/kg) produced significantly high titers of total OVA specific or TT specific IgG1 and IgG2a compared with the levels in untreated control. Oral administration of AAAJ or BGPA (100, 200, or 400 mg/kg) evoked a significant increase in carbon clearance at all doses, indicating stimulation of the reticuloendothelial system, and potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells (SRBC) compared with the untreated mice. Total lymphocyte count, neutrophil count, and lymphocytes count increased significantly (P < 0.05) at all doses, following acute administration of AAAJ or BGPA (100, 200, or 400 mg/kg), showing increased protection toward cyclophosphamide induced myelosuppression compared with the untreated negative control group. In the hemolytic complement assay, AAAJ and BGPA at all doses significantly (P < 0.05) inhibited the hemolytic activity of the complement proteins on the sensitized SRBC. The present study reveals that the extract holds promise as an immunomodulatory agent and strengthens the rationale for its use in traditional medicine.

REFERENCIAS

  1. Wasser SP. Medicinal mushrooms in human clinical studies. Part I. Anticancer, oncoimmunological, and immunomodulatory activities: A review. Int J Med Mushrooms. 2017;19(4):279-317.

  2. Vunduk J, Klaus A, Kozarski M, Petrovic P, Zizak Z, Niksic M, Griensven LJ. Did the iceman know better? Screening of the medicinal properties of the birch polypore medicinal mushroom, Piptoporus betulinus (higher Basidiomycetes). Int J Med Mushrooms. 2015;17(12):1113-25.

  3. Zmitrovich VI, Belova NV, Balandaykin ME, Bondartseva MA, Wasser SP. Cancer without pharmacological illusions and a niche for mycotherapy (Review). Int J Med Mushrooms. 2019;21(2):105-19.

  4. Wasser SP. Medicinal mushroom science: History, current status, future trends, and unsolved problems. Int J Med Mushrooms. 2010;12(1):1-16.

  5. Boh B, Berivic M. Grifola frondosa (Diks.: Fr) S.F. Gray (maitake mushroom): Medicinal properties, active compounds and biological cultivation. Int J Med Mushrooms. 2007;9:89-108.

  6. Maruyama H, Ikekawa T. Immunomodulatory and antitumor activity of a mushroom product, Proflamin isolated from Flammulina velutipes (W. Curt.: Fr.) Singer (Agaricomycetidae). Int J Med Mushrooms. 2007;9:109-22.

  7. Wu JM, Doonan BB, Hsieh T-C, Yang Q, Yang XT, Ling M-T. Recent advances and challenges in studies and control of cancer stem cells and the gut microbiome by the Trametes-derived polysaccharopeptide PSP (review). Int J Med Mushrooms. 2016;18(5):651-60.

  8. Gao Y, Zhou S, Huang M, Xu A. Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (Aphyllophoromycetidae): A review. Int J Med Mushrooms. 2003;5:235-46.

  9. Pirano F. Emerging antiviral drugs from medicinal mushrooms. Int J Med Mushrooms. 2006;8:101-14.

  10. Mizuno T, Zhuang C, Abe K, Okanioto H, Kiho T, Ukai S, Leclerc S, Meijer L. Antitumor and hypoglycemic activities of polysaccharides from the sclerotia and mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetidae). Int J Med Mushrooms. 1999;1(3):301-16.

  11. Gao Y, Lan J, Dai X, Ye J, Zhou S. A phase I/II study of Ling Zhi mushroom Ganoderma lucidum (W. Curt.: Fr.) Lloyd (Aphyllophoromycetidae) extract in patients with type II diabetes mellitus. Int J Med Mushrooms. 2004;6:96-107.

  12. Pandey VV, Kumari A, Kumar M, Saxena J, Kainthola C, Pandey A. Mushroom cultivation: substantial key to food security. J Appl Nat Sci. 2018;10(4):1325-31.

  13. Sachin G, Baby S, Moni G. Edible mushrooms: Cultivation, bioactive molecules and health benefits. In: Merillon JM, Ramawat K, editors. Bioactive molecules in food. Reference series in phytochemistry. Cham, Switzerland: Springer: 2018, p. 1-33.

  14. Agnieszka S, Anddrzej K, Aneta G, Marek S. Auricularia spp.- mushrooms as novel food and therapeutic agents - a review. Sydowia Horn. 2017;67:1-10.

  15. Packialaksgmi B, Sudha G, Charumathy M. Studies on phytochemical compounds and antioxidant potential of Auricularia auricula-judae. Int J Pharm Sci Res. 2017;8(8):3508-15.

  16. Vetter J. Biological values of cultivated mushrooms-a review. Acta Alimentaria. 2019;48(2):229-40.

  17. Samsudin NIP, Abdullah N. Edible mushrooms from Malaysia; a literature review on their nutritional and medicinal properties. Int Food Res J. 2019;26(1):11-31.

  18. Jones K. Maitake: A potent medicinal food. Alt Comparative Ther. 1998;4:420-9.

  19. Huang HY, Korivi M, Chaing YY, Chang YY, Chien T, Tsai YC. Pleurotus tuberregium polysaccharides attenuates hyperglycemia and oxidative stress in experimental diabetic rats. Evid Based Complement Alternat Med. 2012;856381.

  20. Nworu CS, Ihim SA, Ugwu LE, Laiyema KA, Akah PA. Hepato and nephroprotective activities of a Nigerian local king tuber Oyster mushroom, Pleurotus tuberrregium (higher Basidiomycetes) in chemically-induced organ toxicities in rats. Int J Med Mushrooms. 2014;16(4):305-18.

  21. Evans WC. Trease and Evans' pharmacognosy. 16th ed. Edinburgh: WB Saunders; 2009.

  22. Harborne JB. Phytochemical methods: A guide to modern techniques of plant analysis. 3rd ed. London: Chapman & Hall, 1998.

  23. Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol. 1983;54:275-87.

  24. Nworu CS, Ihim SA, Okoye FC, Esimone CO, Adiku MU, Akah PA. Immunomodulatory and immunorestorative activities of &#946;-D-glucan-rich extract and polysaccharide fraction of mushroom Pleurotus tuberregium. Pharm Biol. 2015;53(11):1-12.

  25. Pan H, Han Y, Huang J, Yu X, Jiao C, Yang X, Dhaliwal P, Xie Y, Yang BB. Purification and identification of a polysaccharide from medicinal mushroom, Amauroderma rude with immunomodulatory activity and inhibitory effect on tumor growth. Oncotarget. 2015;6:17777-91.

  26. Beck L, Spiegelberg HL. The polyclonal and antigen-specific IgG and IgE subclass response of mice injected with ovalbumin in alum or complete Freund's adjuvant. Cell Immunol. 1989;123:1-8.

  27. Zhang X, Li J, Wong DKW, Wagner TE, Wei Y. Fermented non exudates-treated dendritic cells directly stimulate B lymphocyte proliferation and differentiation. Oncol Rep. 2009;21:1147-52.

  28. Vivek KC, Sonam A, Krishna KG, Pramod WR, Singh MP. Medicinal mushroom: Boon for therapeutic applications. 3Biotech. 2018;8(334):1-20.

  29. Santun BR, Dhiah D, Arto YS, Tatang B. The phytochemical screening, total phenolic contents and antioxidant activities in invitro of white Oyster Mushroom (Pleurotus ostreatus) preparations. Open Access Maced J Med Sci. 2019;7(15):2404-12.

  30. Mahamat O, Andre-Ledoux N, Chrisopher T, Abamukong AM, Kamanyi A. Assessment of antimicrobial and immunomodulatory activities of termite associated fungi, Termitomyces clypeatus R. Heim (Lyophyllaceae, Basidiomycota). Clin Phytosci. 2018;4:28.

  31. Gabriel L, Humberto JM, Yamila L, Adrian G, Roberto F, Rosa CB, Isabelle P. Phytochemical screening and effects on cell-mediated immune response of Pleurotus fruiting bodies powder. Food Agric Immunol. 2013;24(3):295-304.

  32. Jaweria N, Imtiaz M, Haseeb A, Muhammad U, Ghulam H, Muhammad I, Muhammad N, Shazia B, Abdul B. Shiitake culinary medicinal mushroom, Lentinus edodes (Aagricomycetes): A species with antioxidant, immunomodulatory and hepatoprotective activities in hypercholesterolemic rats. Int J Med Mushrooms. 2017;19(1):980-90.

  33. Mazumder Peter AA. Potential of mushroom compounds as immunomodulators in cancer immunotherapy: A review. Evid Based Complement Alternat Med. 2018:2018;7271509.

  34. Daisuke H, Tomoya I, Hiroshi N. The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis. Int J Mol Sci.2018;19(1):92.

  35. Ashok A, Shabudeen PSS. Phytochemical qualitative analysis and immunomodulator activity of Agaricus bisporous ethanol extract by carbon clearance technique. Biochem Pharmacol. 2015;4(2):168.

  36. Yu-Hsing L, Jong-Tar K, Yun-Yu C, Kumar KJ, Chiu-Ping L, Chin-Chung L, Sheng-Yang W. Immunomodulatory effects of the stout camphor medicinal mushroom, Taiwanofungus camphoratus (Agaricomycetes)-based health food product in mice. Int J Med Mushrooms. 2018;20(9):849-58.

  37. Shruthi S, Vijayalaxmi KK, Shenoy KB. Immunomodulatory effects of gallic acid against cyclophosphamide and cisplastin induced immunosuppression in Swiss albino mice. Ind J Pharm Sci. 2018;80(1):150-60.

  38. Yu C, Xiaowei X, Shujing L, Linfang H, Jian G. Ganoderma: A cancer immunotherapy review. Front Pharmacol. 2018;9:1217.

  39. Hou FX, Hui FY, Tao Y, Wei C. The immunosuppressive effects of 10 mg/kg cyclophosphamide in Wistar rats. Environ Toxicol Pharmacol. 2007;24:30-36.

  40. Wang X, Chu Q, Jiang X, Yue Y, Libian W, Yaqi C, Jiahui L, Lirong T, Di W. Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway. Cell Death Dis. 2018;9(6):578.

  41. Saswati P, Jeak LD. Natural antibodies bridge innate and adaptive immunity. J Immunol. 2015;194(1):13-20.

  42. Benacerraf B. Hypothesis to relate the specificity of T lymphocyte and the activity of I region specific Ir genes in macrophages and B lymphocytes. J Immunol. 1978;120:1809-12.

  43. Pier GB, Lyczak JB, Wetzler LM. Cell mediated immunity in Blackwell Publishing. Immunology, infection and immunity. Washington, D.C: Asm Press, 2004.

  44. Sanjay R, Lisa L, Peter A. Infections of people with complement deficiencies and people who have undergone spleenoctomy. Clin Microbiol Rev. 2010;23(4):740-80.

  45. Lull C, Wichers HJ, Savelkoul HFJ. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005;9(2):63-80.


Articles with similar content:

Immunomodulating and Antiprotozoal Effects of Different Extracts of the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Higher Basidiomycetes) Against Coccidiosis in Broiler
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 3
Zafar Iqbal, Masood Akhtar, Muhammad Shahid, Muhammad Irfan Ullah, Mian Muhammad Awais
Pharmacological Studies on Certain Mushrooms from China
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 4
Vincent Eng Choo Ooi
Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 2
Michael T. Sobowale, Raymond I. Ozolua, Buniyamin A. Ayinde, Dickson O. Uwaya
Water-Soluble Polysaccharides of Ganoderma lucidum (W.Curt.:Fr.) P. Karst. (Aphyllophoromycetideae) Alleviate the Dose-Limiting Toxicities of Irinotecan (CPT-11)
International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 4
Xiaoxia Yang, Yihuai Gao, Zeping Hu, Shufeng Zhou, Xiao Chen
Immunomodulatory Effects of the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes)-Based Health Food Product in Mice
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 9
Chin-Chung Lin, K. J. Senthil Kumar, Chiu-Ping Lo, Sheng-Yang Wang, Jong-Tar Kuo, Yun-Yu Chen, Yu-Hsing Lin