Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i6.50
pages 541-556

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function

Ya-Hui Chen
Department of Medical Education and Research, Changhua Christian Hospital, #135 Nanxiao Street, Changhua City, Changhua County 50006, Taiwan
Chien-Hsing Lee
School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan R.O.C.; Division of Pediatric Surgery, Department of Surgery, China Medical University Children's Hospital, Taichung, 40402, Taiwan R.O.C.
Tai-Hao Hsu
Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); Department of Bioindustry Technology, Da-Yeh University, Datsuen, Changhua, 51591, Taiwan (R. O. C.); bDepartment of Food Science and Biotechnology, Da-Yeh University, Taiwan, R.O.C
Hui-Chen Lo
Department of Nutritional Science, Fu Jen Catholic University, #510, JhongZheng Rd., Xinzhuang District, New Taipei City, 24205, Taiwan, ROC

SINOPSIS

Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats. Herein, we investigated the immunomodulatory effects of the submerged-culture mycelia and broth of G. frondosa on the peripheral blood cells (PBL) and splenocytes. Male Wistar rats were administered with saline (normal rats) or streptozotocin plus nicotinamide (T2DM rats) and were intragastrically administered with placebo, fermented mycelia, broth, or mycelia plus broth (1 g kg−1 day−1) for two weeks. In normal rats, ingestion of mycelia significantly decreased monocytes and ingestion of mycelia and broth significantly decreased the productions of interferon (IFN)-γ and interleukin (IL)-4 from the PBL and splenocytes. In T2DM rats, ingestion of mycelia, broth, and mycelia plus broth significantly alleviated the increases in 2 h postprandial blood glucose and the productions of IFN-γ from the T-leukocytes, IL-4, and IL-6 from the monocytes and IL-4 from the T-splenocytes, as well as significantly improved the productions of tumor-necrosis factor-α from the macrophages. In conclusion, submerged-culture mycelia and broth of G. frondosa may decrease cell-medicated immunity in normal rats and improve hyperglycemia and diabetes-induced alterations in cell-medicated and innate immunities in T2DM rats.


Articles with similar content:

Effects of Yellow Brain Culinary-Medicinal Mushroom, Tremella mesenterica Ritz.:Fr. (Higher Basidiomycetes), on Immune Function in Normal and Type 1 Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 5
Solomon P. Wasser, Fang-Yi Lin, Chien-Hsing Lee, Yu-Hsin Chen, Tai-Hao Hsu, Hui-Chen Lo
Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Haseeb Anwar, Jaweria Nisar, Ghulam Hussain, Shazia Anwer Bukhari, Muhammad Naeem Faisal, Muhammad Irfan Ullah, Abdul Basit, Imtiaz Mustafa, Muhammad Umar Sohail
MT-α-Glucan from the Fruit Body of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomyetes) Shows Protective Effects for Hypoglycemic Pancreatic β-Cells
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Hong Lei, Shuzhen Guo, Qin Wang, Hanju Sun, Juncheng Han, Wutong Wu, Minmin Zhang
Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes) in a Nonalcoholic Fatty Liver Disease Rat Model
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 8
Erenius Toppo, Naif Abdhullah Al-Dhabi, Savarimuthu Ignacimuthu, Perumal Pandikumar, Ramar Govindaraj, Michael Gabriel Paulraj
Turmeric Bioprocessed with Mycelia from the Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Protects Mice Against Salmonellosis
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 4
Sung Phil Kim, Seok Hyun Nam, Mendel Friedman, Sang Jong Lee