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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

An Immunomodulating Polysaccharide in Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) Activates Macrophages through Toll-like Receptor 4

Volumen 8, Edición 3, 2006, pp. 223-229
DOI: 10.1615/IntJMedMushr.v8.i3.40
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SINOPSIS

Peritoneal macrophages from toll-like receptor (TLR) 4 and TLR2 knockout mice (TLR4−/− and TLR2−/−) were stimulated with a water-insoluble hetero-glycan (ABHG), purified from a fruit body of Agaricus brasiliensis. TLR4−/− mice did not produce tumor necrosis factor (TNF)−α and nitric oxide (NO), but TLR2−/− did. However, ABHG did not inhibit TNF-α and NO production by macrophages in the presence of polymyxin B, which could bind to lipid A in lipopolysaccharide (LPS); suggesting that ABHG did not contain LPS as contaminants. These results indicated that ABHG was recognized through TLR4−/− to produce inflammatory cytokines such as TNF-α and NO. RT-PCR was used to investigate the effect of ABHG on mRNA expression of TNF-α and inducible nitric oxide synthase (iNOS) in RAW 264.7. TNF-α mRNA expression was induced 0.5 hr after stimulation, peaked in 3 hr, and thereafter decreased to reach a stable level after 24 hr. On the other hand, iNOS mRNA induction was delayed for 3 hr and thereafter remained at the same level until 24 hr after stimulation. Furthermore, the DNA binding activity of NF-κB was observed as early as 0.5 hr after treatment and rapidly increased to its peak value 2 hr later, and thereafter decreased. When RAW 264.7 was stimulated with ABHG in the presence of an anti-TNF-α antibody, TNF-α mRNA expression was not affected and iNOS was downregulated. These results indicate that TNF-α production by RAW 264.7, stimulated with an immunomodulating polysaccharide such as ABHG, was enhanced by upregulating of NF-κB through TLR4, and the newly produced TNF-α enhanced NO production trough an autocrine pathway.

CITADO POR
  1. Souza Dias Eustáquio, Labory Cláudia Regina Gontijo, Herrera Karina Marjorie Silva, Alves Alexandre Alonso, Torres Giovana Augusta, Rinker Danny Lee, Cytological studies of Agaricus brasiliensis, World Journal of Microbiology and Biotechnology, 24, 11, 2008. Crossref

  2. Yamanaka Daisuke, Motoi Masuro, Ishibashi Ken-ichi, Miura Noriko N., Adachi Yoshiyuki, Ohno Naohito, Effect ofAgaricus brasiliensis-derived cold water extract on Toll-like receptor 2-dependent cytokine productionin vitro, Immunopharmacology and Immunotoxicology, 34, 4, 2012. Crossref

  3. Navegantes Kely C., Albuquerque Rosyana F. V., Dalla-Santa Herta S., Soccol Carlos R., Monteiro Marta C., Agaricus brasiliensismycelium and its polysaccharide modulate the parameters of innate and adaptive immunity, Food and Agricultural Immunology, 24, 4, 2013. Crossref

  4. Dias Eustáquio Souza, Mushroom cultivation in Brazil: challenges and potential for growth, Ciência e Agrotecnologia, 34, 4, 2010. Crossref

  5. Mizuno Masashi, In Vitro and In Vivo Immunomodulatory and Anti-allergic Effects of Agaricus blazei Murill, in Dietary Components and Immune Function, 2010. Crossref

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