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International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumes:
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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2018026241
pages 485-494

Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice

Paola Rossi
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy
Valentina Cesaroni
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy; Department of Earth and Environmental Science (DSTA), University of Pavia, Pavia, Italy
Federico Brandalise
Brain Research Institute, University of Zurich, Zurich, Switzerland
Alessandra Occhinegro
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy
Daniela Ratto
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy
Fabio Perrucci
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy
Veralice Lanaia
Department of Biology and Biotechnology "L. Spallanzani" (DBB), University of Pavia, Pavia, Italy
Carolina Girometta
Department of Earth and Environmental Science (DSTA), University of Pavia, Pavia, Italy
Germano Orrù
O.B.L. Department of Surgical Sciences, University of Cagliari, Cagliari, Italy
Elena Savino
Department of Earth and Environmental Science (DSTA), University of Pavia, Pavia, Italy

SINOPSIS

Hericium erinaceus is an edible and medicinal mushroom with potential neuroprotective effects. The study of H. erinaceus has attracted considerable attention during the past 10 years, particularly with regard to its potential utility in the treatment of motor dysfunction, Alzheimer disease, and other forms of dementia. We previously determined that oral supplementation with H. erinaceus results in significant improvements in novelty-seeking behavior and novel object recognition in mice. In this study, H. erinaceus was added to the diets of wild-type mice for 2 months, and effects on spatial memory were evaluated by means of a Y maze and an object location task. We found that H. erinaceus increased general locomotor activity but had no effect on spatial memory. Thus, oral supplementation with H. erinaceus yields specific and selective improvements in recognition memory without altering spatial working memory, which supports the hypothesis that recognition memory can be modeled as a dual process. In this model, the perirhinal cortex supports the recognition of individual items as part of a circuit involved in familiarity with an encountered stimulus, whereas the hippocampus supports recollected associations and relationships between stimuli.


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