Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i3.20
9 pages

Extraction of Conformationally Stable (1®6)-Branched (1®3)-b-Glucans from Premixed Edible Mushroom Powders by Cold Alkaline Solution

Masaji Sawai
Takara Agri Co., Ltd., 2257 Noji, Kusatsu, Shiga, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Manabu Kanai
Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392;Japan
Susumu Matsui
Takara Agri Co., Ltd., 2257 Noji, Kusatsu, Shiga, Japan
Toshiro Yadomae
Laboratory of Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


(1®3)-b-glucan content in extracts from various edible mushrooms was measured by using a (l®-6)-branched (1®3)-b-glucan-specific enzyme immune system. Comparing (1®3)-b-glucan content in hot water extracts or cold alkaline extracts of each edible mushroom, it was shown that Lentinus edodes (Berk.) Sing. contained higher levels of (1®3)-b-glucan than any of the other mushrooms. Cold alkaline extract possessed the highest amount of (1®3)-b-glucans. Interestingly, a cold alkaline extract from premixed dried powder of the mushrooms showed a higher level of (1®3)-b-glucan following calculation as sonifilan than the theoretical total amount of each (1®3)-b-glucan extract from each constituent mushroom from which premixed dried powder was prepared. Considering the specificity of this enzyme immunoassay as previously reported, it is suggested that premixed extraction contains Conformationally stable (1®3)-b-glucans. Antitumor activity of these mushroom extracts was also tested using a murine experimental model. All of the extracts showed higher antitumor activity and the effectiveness on inhibition of tumor growth in sold form was almost equal. Activation of macrophages by co-cultivation with the various extracts was induced with the premixed extract significantly higher. Induction of interferon-y was also enhanced by administration of the premixed extract. The premix extract showed modulating effect on glucocorticoid release induced by restraint stress. These results suggest that the mixture of mushroom extracts may provide physicochemically stable (1®3)-b-glucans and physiologically active products. A complementary effect of each mushroom component on enhancing immunological function would be expected by the mixed extraction.font face=

Articles with similar content:

Structure and Antitumor Activity of 1,3-b-Glucan from Cultivated Fruit Bodies of Culinary–Medicinal Mushroom Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 3
Shigeyuki Goto, Naohito Ohno, Masuro Motoi
Immunomodulating Effects Exerted by Glucans Extracted from the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Grown in Substrates Containing Various Concentrations of Olive Mill Waste
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 8
Yitzhak Hadar, Vaclav Vetvicka, Nirit Ezov, Betty Schwartz, Ofer Gover, Ofer Danay, Hilla Hayby
The Influence of Selected Higher Basidiomycetes on the Binding of Lipopolysaccharide to CD14+ Cells and on the Release of Cytokines
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 3
Jacqueline Koch, Ulrike Lindequist, Sabine Witt
Antioxidant and Anti-Inflammatory Properties of Solid-State Fermented Products from a Medicinal Mushroom, Taiwanofungus salmoneus (Higher Basidiomycetes) from Taiwan
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 1
Shen-Shih Chiang, Jeng-Leun Mau, Enkhjargal Ulziijargal , Rao-Chi Chien
Antitumor Polysaccharides from Edible and Medicinal Mushrooms and Immunomodulating Action Against Murine Macrophages
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 4
Hitoshi Ashida, Takashi Hashimoto, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno