Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
International Journal of Medicinal Mushrooms
Factor de Impacto: 1.423 Factor de Impacto de 5 años: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344

Volumen 22, 2020 Volumen 21, 2019 Volumen 20, 2018 Volumen 19, 2017 Volumen 18, 2016 Volumen 17, 2015 Volumen 16, 2014 Volumen 15, 2013 Volumen 14, 2012 Volumen 13, 2011 Volumen 12, 2010 Volumen 11, 2009 Volumen 10, 2008 Volumen 9, 2007 Volumen 8, 2006 Volumen 7, 2005 Volumen 6, 2004 Volumen 5, 2003 Volumen 4, 2002 Volumen 3, 2001 Volumen 2, 2000 Volumen 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i3.70
pages 277-286

The Effect of the Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes) on the Erythron System in Normal and Streptozotocin-Induced Diabetic Rats

Taras Y. Vitak
Department of Evolutionary and Environmental Biology, Faculty of Natural Science, University of Haifa, Mount Carmel, Haifa, Israel
Solomon P. Wasser
International Centre for Biotechnology and Biodiversity of Fungi Institute of Evolution and Faculty of Natural Sciences University of Haifa, Mt. Carmel, Haifa 31905, Israel
Eviatar D. Nevo
Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, Institute of Evolution, University of Haifa, 199 Abba Khousi Ave., Mt. Carmel, Haifa 3498838, Israel
Nataliya O. Sybirna
Department of Biochemistry Ivan Franko Lviv National University 4 Hrushevsky St., Lviv 79005 Ukraine


Diabetes mellitus (DM) is accompanied by the development of hypoxia, which disturbs the physicochemical properties of the erythrocyte membrane and further leads to the occurrence of anemia and a reduction of the lifespan. In response, the body activates compensatory reactions directed at a renewal of the red blood cell pool and an increase in tissue oxygenation. In this study the influence of Agaricus brasiliensis and Ganoderma lucidum medicinal mushroom mycelia on the erythron system of control and streptozotocin (STZ)-induced diabetic rats were investigated. Wistar outbred white male rats were intraperitoneally injected with saline (control rats) or STZ (50 mg/kg, DM rats) and orally treated with placebo or submerged culture mycelium powder (1 g/kg/day) for 2 weeks. Peripheral blood erythrocytes were collected. Hypoglycemic effects of A. brasiliensis and G. lucidum occurred in the diabetic rats, as evidenced by decreased blood glucose and glycosylated hemoglobin concentrations. In STZ-diabetic animals treated with submerged culture mycelium powder, an increase in the number of erythrocytes in the bloodstream (an antianemic effect), erythrocyte resistance to acid hemolysis, and the normalization of fetal hemoglobin concentrations, along with the intensification of erythropoiesis were observed. In conclusion, our results suggest that in diabetic animals A. brasiliensis and G. lucidum have therapeutic effects that manifest in hypoglycemic and antianemic action.