Suscripción a Biblioteca: Guest
Critical Reviews™ in Neurobiology

Publicado 3 números por año

ISSN Imprimir: 0892-0915

ISSN En Línea: 2375-0014

SJR: 0.121

Hippocampal Long-Term Synaptic Plasticity and Signal Amplification of NMDA Receptors

Volumen 18, Edición 1-2, 2006, pp. 71-84
DOI: 10.1615/CritRevNeurobiol.v18.i1-2.80
Get accessGet access

SINOPSIS

The direction of plasticity at CA3-CA1 hippocampal synapses is determined by the strength of afferent stimulation. Weak stimuli lead to long-term depression (LTD) and strong stimuli to long-term potentiation (LTP), but both require activation of synaptic N-methyl-D-aspartate receptors (NMDARs). These receptors are therefore necessary and required for the induction of plasticity at CA3-CA1 synapses even though they carry little of the current responsible for the basal excitatory post-synaptic potential (EPSP). The influx of Ca2+ via NMDARs triggers the subsequent and persistent changes in the expression of α-amino-3-hydroxy-5 methylisoxazole-4-proprionic acid receptors (AMPARs) and these receptors are responsible for the major part of the basal EPSP. The degree of activity of NMDARs is determined in part by extracellular Mg2+ and by the co-agonists for this receptor, glycine and D-serine. During strong stimulation, a relief of the voltage-dependent block of NMDARs by Mg2+ provides a positive feedback for NMDAR Ca2+ influx into postsynaptic CA1 spines. In this review, we discuss how the induction of LTP at CA3-CA1 synapses requires further signal amplification of NMDAR activity. We discuss how the regulation of NMDARs by protein kinases and phosphatases is brought into play. Evidence is presented that Src family kinases (SFKs) play a "core" role in the induction of LTP by enhancing the function and expression of NMDARs. At CA3-CA1 synapses, NMDARs are largely composed of NR1 (NMDA receptor subunit 1)-NR2A or NR1-NR2B containing subunits. Recent, but controversial, evidence has correlated NR1-NR2A receptors with the induction of LTP and NR1-NR2B receptors with LTD. However, LTP can be induced by activation of either subtype of NMDAR and the ratio of NR2A:NR2B receptors has been proposed as an alternative determinant of the direction of synaptic plasticity. Many transmitters and signal pathways can modify NMDAR function and expression and, for a given stimulus strength, they can potentially lead to a change in the balance between LTP and LTD. As opposed to the "core" mechanisms of LTP and LTD, the resulting alterations in this balance underlie "meta-plasticity." Thus, in addition to their contribution to core mechanisms, we will also discuss how Src-family kinases could preferentially target NR1-NR2A or NR1-NR2B receptors to alter the relative contribution of these receptor subtypes to synaptic plasticity.

CITADO POR
  1. Nashawi H., Bartl T., Bartl P., Novotny L., Oriowo M.A., Kombian S.B., TH-9 (a theophylline derivative) induces long-lasting enhancement in excitatory synaptic transmission in the rat hippocampus that is occluded by frequency-dependent plasticity in vitro, Neuroscience, 220, 2012. Crossref

  2. Shin Tae-Joon, Kim Hyeon-Joong, Kwon Byeong-Jae, Choi Sun-Hye, Kim Hyun-Bum, Hwang Sung-Hee, Lee Byung-Hwan, Lee Sang-Mok, Zukin R. Suzanne, Park Ji-Ho, Kim Hyoung-Chun, Rhim Hyewhon, Lee Joon-Hee, Nah Seung-Yeol, Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: Involvement of LPA receptors, Molecules and Cells, 34, 6, 2012. Crossref

  3. Yao Zhi-Gang, Liu Yu, Zhang Ling, Huang Lan, Ma Chun-Mei, Xu Yan-Feng, Zhu Hua, Qin Chuan, Co-location of HDAC2 and Insulin Signaling Components in the Adult Mouse Hippocampus, Cellular and Molecular Neurobiology, 32, 8, 2012. Crossref

  4. Gan J, Greenwood SM, Cobb SR, Bushell TJ, Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2, British Journal of Pharmacology, 163, 5, 2011. Crossref

  5. Banks P.J., Bashir Z.I., Brown M.W., Recognition memory and synaptic plasticity in the perirhinal and prefrontal cortices, Hippocampus, 22, 10, 2012. Crossref

  6. Kim Eun-Jung, Monje Francisco J., Li Lin, Höger Harald, Pollak Daniela D., Lubec Gert, Alzheimer’s disease risk factor lymphocyte-specific protein tyrosine kinase regulates long-term synaptic strengthening, spatial learning and memory, Cellular and Molecular Life Sciences, 70, 4, 2013. Crossref

  7. Gidon Albert, Segev Idan, Principles Governing the Operation of Synaptic Inhibition in Dendrites, Neuron, 75, 2, 2012. Crossref

  8. Li Hong-Bin, Jackson Michael F., Yang Kai, Trepanier Catherine, Salter Michael W., Orser Beverley A., MacDonald John F., Plasticity of synaptic glun receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses, Hippocampus, 21, 10, 2011. Crossref

  9. Scharfman Helen E., Binder Devin K., Aquaporin-4 water channels and synaptic plasticity in the hippocampus, Neurochemistry International, 63, 7, 2013. Crossref

  10. Watanabe Kanako, Kanno Takeshi, Oshima Tadayuki, Miwa Hiroto, Tashiro Chikara, Nishizaki Tomoyuki, The NMDA receptor NR2A subunit regulates proliferation of MKN45 human gastric cancer cells, Biochemical and Biophysical Research Communications, 367, 2, 2008. Crossref

  11. Rodríguez-Molina Víctor, Vargas Miguel Ángel, Joseph-Bravo Patricia, Charli Jean-Louis, NMDA receptor up-regulates pyroglutamyl peptidase II activity in the rat hippocampus, Neuroscience Letters, 449, 3, 2009. Crossref

  12. Rendeiro Catarina, Foley Andrew, Lau Vera C., Ring Rebecca, Rodriguez-Mateos Ana, Vauzour David, Williams Claire M., Regan Ciaran, Spencer Jeremy P.E., A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats, Neuropharmacology, 79, 2014. Crossref

  13. Nyberg Fred, Hallberg Mathias, Growth hormone and cognitive function, Nature Reviews Endocrinology, 9, 6, 2013. Crossref

  14. Heresco-Levy Uriel, Shoham Shai, Javitt Daniel C., Glycine site agonists of theN-methyl-d-aspartate receptor and Parkinson's disease: A hypothesis, Movement Disorders, 28, 4, 2013. Crossref

  15. Malcher‐Lopes Renato, Buzzi Marcelo, Chapter 11 Glucocorticoid‐Regulated Crosstalk Between Arachidonic Acid and Endocannabinoid Biochemical Pathways Coordinates Cognitive‐, Neuroimmune‐, and Energy Homeostasis‐Related Adaptations to Stress, in Vitamins and Hormones, 81, 2009. Crossref

  16. Brady Scott T., Lau Lit-Fui, Tyrosine Phosphorylation, in Basic Neurochemistry, 2012. Crossref

  17. Chang Hung-Ming, Liao Wen-Chieh, Sheu Ji-Nan, Chang Chun-Chao, Lan Chyn-Tair, Mai Fu-Der, Sleep Deprivation Impairs Ca2+ Expression in the Hippocampus: Ionic Imaging Analysis for Cognitive Deficiency with TOF-SIMS, Microscopy and Microanalysis, 18, 3, 2012. Crossref

  18. Di Maio Roberto, Mastroberardino Pier G., Hu Xiaoping, Montero Laura, Greenamyre J. Timothy, Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms, Neurobiology of Disease, 42, 3, 2011. Crossref

  19. Tabakoff Boris, Hoffman Paula L., The neurobiology of alcohol consumption and alcoholism: An integrative history, Pharmacology Biochemistry and Behavior, 113, 2013. Crossref

  20. Mota Sandra I., Ferreira Ildete L., Rego A. Cristina, Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors, Neuropharmacology, 76, 2014. Crossref

  21. Kharlamov Elena A., Lepsveridze Eka, Meparishvili Maia, Solomonia Revaz O., Lu Bo, Miller Eric R., Kelly Kevin M., Mtchedlishvili Zakaria, Alterations of GABAA and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy, Epilepsy Research, 95, 1-2, 2011. Crossref

  22. Banks P.J., Warburton E.C., Brown M.W., Bashir Z.I., Mechanisms of Synaptic Plasticity and Recognition Memory in the Perirhinal Cortex, in Molecular Basis of Memory, 122, 2014. Crossref

  23. Paula-Lima Andrea C., Adasme Tatiana, Hidalgo Cecilia, Contribution of Ca2+Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation, Antioxidants & Redox Signaling, 21, 6, 2014. Crossref

  24. Goracci Gianfrancesco, Ferrini Monica, Nardicchi Vincenza, Low Molecular Weight Phospholipases A2 in Mammalian Brain and Neural Cells: Roles in Functions and Dysfunctions, Molecular Neurobiology, 41, 2-3, 2010. Crossref

  25. Wonodi I., Schwarcz R., Cortical Kynurenine Pathway Metabolism: A Novel Target for Cognitive Enhancement in Schizophrenia, Schizophrenia Bulletin, 36, 2, 2010. Crossref

  26. Ong Wei-Yi, Kim Ji-Hyun, He Xin, Chen Peng, Farooqui Akhlaq A., Jenner Andrew M., Changes in Brain Cholesterol Metabolome After Excitotoxicity, Molecular Neurobiology, 41, 2-3, 2010. Crossref

  27. Stys Peter K., You Haitao, Zamponi Gerald W., Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders, The Journal of Physiology, 590, 6, 2012. Crossref

  28. Brennan Angela M, Won Suh Sang, Joon Won Seok, Narasimhan Purnima, Kauppinen Tiina M, Lee Hokyou, Edling Ylva, Chan Pak H, Swanson Raymond A, NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation, Nature Neuroscience, 12, 7, 2009. Crossref

  29. Krnjević Krešimir, When and why amino acids?, The Journal of Physiology, 588, 1, 2010. Crossref

  30. Youn Dong-ho, Gerber Gábor, Sather William A., Ionotropic Glutamate Receptors and Voltage-Gated Ca2+Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity, Neural Plasticity, 2013, 2013. Crossref

  31. Watanabe Kanako, Kanno Takeshi, Oshima Tadayuki, Miwa Hiroto, Tashiro Chikara, Nishizaki Tomoyuki, Vagotomy upregulates expression of the N-methyl-d-aspartate receptor NR2D subunit in the stomach, Journal of Gastroenterology, 43, 5, 2008. Crossref

  32. Joëls Marian, Karst Henk, Corticosteroid effects on calcium signaling in limbic neurons, Cell Calcium, 51, 3-4, 2012. Crossref

  33. Spellmann Ilja, Rujescu Dan, Musil Richard, Giegling Ina, Genius Just, Zill Peter, Dehning Sandra, Cerovecki Anja, Seemüller Florian, Schennach Rebecca, Hartmann Annette M., Schäfer Martin, Müller Norbert, Möller Hans-Jürgen, Riedel Michael, Pleckstrin homology domain containing 6 protein (PLEKHA6) polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 51, 2014. Crossref

  34. Liu Xiuping, Basavaraj Sidhesh, Krishnan Ramya, Yan Jun, Contributions of the thalamocortical system towards sound-specific auditory plasticity, Neuroscience & Biobehavioral Reviews, 35, 10, 2011. Crossref

  35. Wang Fei, Geng Xin, Tao Hua-Ying, Cheng Yan, The Restoration After Repetitive Transcranial Magnetic Stimulation Treatment on Cognitive Ability of Vascular Dementia Rats and Its Impacts on Synaptic Plasticity in Hippocampal CA1 Area, Journal of Molecular Neuroscience, 41, 1, 2010. Crossref

  36. Vallés Ana S., Barrantes Francisco J., Chaperoning α7 neuronal nicotinic acetylcholine receptors, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818, 3, 2012. Crossref

  37. Nguyen Thi Thanh Hoang, Bhattarai Janardhan Prasad, Park Soo Joung, Han Seong Kyu, Activation of Glycine and Extrasynaptic GABAAReceptors by Taurine on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis, Neural Plasticity, 2013, 2013. Crossref

  38. Orfila J. E., Shimizu K., Garske A. K., Deng G., Maylie J., Traystman R. J., Quillinan N., Adelman J. P., Herson P. S., Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation, European Journal of Neuroscience, 40, 8, 2014. Crossref

  39. Hou Yuan-yuan, Liu Yao, Kang Shuo, Yu Chuan, Chi Zhi-qiang, Liu Jing-gen, Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats, Acta Pharmacologica Sinica, 30, 10, 2009. Crossref

  40. Potter Michelle C, Elmer Greg I, Bergeron Richard, Albuquerque Edson X, Guidetti Paolo, Wu Hui-Qiu, Schwarcz Robert, Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior, Neuropsychopharmacology, 35, 8, 2010. Crossref

  41. Davis Michael F., Vigil Dom, Campbell Sharon L., Regulation of Ras proteins by reactive nitrogen species, Free Radical Biology and Medicine, 51, 3, 2011. Crossref

  42. Hildebrand Michael E., Pitcher Graham M., Harding Erika K., Li Hongbin, Beggs Simon, Salter Michael W., GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord, Scientific Reports, 4, 1, 2015. Crossref

  43. Nic Dhonnchadha Bríd Á., Cunningham Kathryn A., Serotonergic mechanisms in addiction-related memories, Behavioural Brain Research, 195, 1, 2008. Crossref

  44. He T., Hirsch H.V.B., Ruden D.M., Lnenicka G.A., Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae, NeuroToxicology, 30, 5, 2009. Crossref

  45. Salter Michael W., Pitcher Graham M., Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia, FEBS Journal, 279, 1, 2012. Crossref

  46. Frisardi Vincenza, Panza Francesco, Seripa Davide, Farooqui Tahira, Farooqui Akhlaq A., Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer’s disease pathology, Progress in Lipid Research, 50, 4, 2011. Crossref

  47. Liu Xiao-Bo, Murray Karl D., Neuronal excitability and calcium/calmodulin-dependent protein kinase type II: Location, location, location, Epilepsia, 53, 2012. Crossref

  48. Groveman Bradley R., Xue Sheng, Marin Vedrana, Xu Jindong, Ali Mohammad K., Bienkiewicz Ewa A., Yu Xian-Min, Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions, FEBS Journal, 278, 4, 2011. Crossref

  49. Tokay Tursonjan, Holl Norman, Kirschstein Timo, Zschorlich Volker, Köhling Rüdiger, High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices, Neuroscience Letters, 461, 2, 2009. Crossref

  50. Bakkar Wafae, Ma Chun-Lei, Pabba Mohan, Khacho Pamela, Zhang Yong-Li, Muller Emilie, Martina Marzia, Bergeron Richard, Chronically saturating levels of endogenous glycine disrupt glutamatergic neurotransmission and enhance synaptogenesis in the CA1 region of mouse hippocampus, Synapse, 65, 11, 2011. Crossref

  51. Gonzalez Fernando F., Ferriero Donna M., Therapeutics for neonatal brain injury, Pharmacology & Therapeutics, 120, 1, 2008. Crossref

  52. Tolias Kimberley F., Duman Joseph G., Um Kyongmi, Control of synapse development and plasticity by Rho GTPase regulatory proteins, Progress in Neurobiology, 94, 2, 2011. Crossref

  53. McCool Brian A., Ethanol modulation of synaptic plasticity, Neuropharmacology, 61, 7, 2011. Crossref

  54. Elhardt Mary, Martinez Luis, Tejada-Simon Maria Victoria, Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice, Neuroscience Letters, 468, 2, 2010. Crossref

  55. D'Souza Deepak Cyril, Singh Nagendra, Elander Jacqueline, Carbuto Michelle, Pittman Brian, de Haes Joanna Udo, Sjogren Magnus, Peeters Pierre, Ranganathan Mohini, Schipper Jacques, Glycine Transporter Inhibitor Attenuates the Psychotomimetic Effects of Ketamine in Healthy Males: Preliminary Evidence, Neuropsychopharmacology, 37, 4, 2012. Crossref

  56. Popov V. A., Markevich V. A., The Key Role of Calcium in the Mechanism of Deprivation Potentiation of Population Responses of Neurons in Hippocampal Field CA1, Neuroscience and Behavioral Physiology, 45, 5, 2015. Crossref

  57. Gonzalez Fernando F., Ferriero Donna M., Neuroprotection in the Newborn Infant, Clinics in Perinatology, 36, 4, 2009. Crossref

  58. Jiang Wei, Yu Qin, Gong Min, Chen Li, Wen En Yi, Bi Yang, Zhang Yun, Shi Yuan, Qu Ping, Liu You Xue, Wei Xiao Ping, Chen Jie, Li Ting Yu, Vitamin A deficiency impairs postnatal cognitive function via inhibition of neuronal calcium excitability in hippocampus, Journal of Neurochemistry, 121, 6, 2012. Crossref

  59. Yamada Kazuyuki, Homma Chihiro, Tanemura Kentaro, Ikeda Toshio, Itohara Shigeyoshi, Nagaoka Yoshiko, Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory, World Journal of Neuroscience, 01, 01, 2011. Crossref

  60. Majdi M., Ribeiro-da-Silva A., Cuello A.C., Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status, Neuroscience, 159, 2, 2009. Crossref

  61. Malá Hana, Chen Yuxia, Worm Vivi Hu, Kure Julie, Kaae Birgitte H., Madsen Ulf, Badolo Lassina, Pickering Darryl S., Mogensen Jesper, Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice, Behavioural Brain Research, 226, 1, 2012. Crossref

  62. Stramiello Michael, Wagner John J., D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs, Neuropharmacology, 55, 5, 2008. Crossref

  63. Park Joo Min, Jung Sung-Cherl, Eun Su-Yong, Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization, The Korean Journal of Physiology & Pharmacology, 18, 6, 2014. Crossref

  64. Holahan Matthew R., Smith Catherine A., Phthalates and neurotoxic effects on hippocampal network plasticity, NeuroToxicology, 48, 2015. Crossref

  65. Izumida Hisakazu, Takagi Hiroshi, Fujisawa Haruki, Iwata Naoko, Nakashima Kohtaro, Takeuchi Seiji, Iwama Shintaro, Namba Takashi, Komatu Yukio, Kaibuchi Kozo, Oiso Yutaka, Arima Hiroshi, Sugimura Yoshihisa, NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats, Experimental Neurology, 287, 2017. Crossref

  66. Al-Onaizi Mohammed A., Parfitt Gustavo M., Kolisnyk Benjamin, Law Clayton S. H., Guzman Monica S., Barros Daniela Martí, Leung L. Stan, Prado Marco A. M., Prado Vania F., Regulation of Cognitive Processing by Hippocampal Cholinergic Tone, Cerebral Cortex, 2016. Crossref

  67. Kanju Patrick M., Parameshwaran Kodeeswaran, Sims-Robinson Catrina, Uthayathas Subramaniam, Josephson Eleanor M., Rajakumar Nagalingam, Dhanasekaran Muralikrishnan, Suppiramaniam Vishnu, Amédée Thierry, Selective Cholinergic Depletion in Medial Septum Leads to Impaired Long Term Potentiation and Glutamatergic Synaptic Currents in the Hippocampus, PLoS ONE, 7, 2, 2012. Crossref

  68. Roy Avik, Modi Khushbu K., Khasnavis Saurabh, Ghosh Supurna, Watson Richard, Pahan Kalipada, Amédée Thierry, Enhancement of Morphological Plasticity in Hippocampal Neurons by a Physically Modified Saline via Phosphatidylinositol-3 Kinase, PLoS ONE, 9, 7, 2014. Crossref

  69. Wu Peter H., Coultrap Steven, Pinnix Chelsea, Davies Kurtis D., Tailor Ramesh, Ang Kian K., Browning Michael D., Grosshans David R., Tofilon Philip J., Radiation Induces Acute Alterations in Neuronal Function, PLoS ONE, 7, 5, 2012. Crossref

  70. Kolomeets N. S., Role of astrocytes in alterations of glutamatergic neurotransmission in schizophrenia, Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 115, 1, 2015. Crossref

  71. Laurén Hanna B., Lopez-Picon Francisco R., Brandt Annika M., Rios-Rojas Clarissa J., Holopainen Irma E., Combs Colin, Transcriptome Analysis of the Hippocampal CA1 Pyramidal Cell Region after Kainic Acid-Induced Status Epilepticus in Juvenile Rats, PLoS ONE, 5, 5, 2010. Crossref

  72. Wen Zunjia, Li Dong, Shen Meifen, Chen Gang, Therapeutic Potentials of Synapses after Traumatic Brain Injury: A Comprehensive Review, Neural Plasticity, 2017, 2017. Crossref

  73. Cibert-Goton Vincent, Yuan Guanglu, Battaglia Anna, Fredriksson Sarah, Henkemeyer Mark, Sears Thomas, Gavazzi Isabella, Sommer Claudia, Involvement of EphB1 Receptors Signalling in Models of Inflammatory and Neuropathic Pain, PLoS ONE, 8, 1, 2013. Crossref

  74. Hahn Britta, Reneski Carolyn H., Pocivavsek Ana, Schwarcz Robert, Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood, Psychopharmacology, 235, 3, 2018. Crossref

  75. Schober Michelle E., McKnight Robert A., Yu Xing, Callaway Christopher W., Ke Xingrao, Lane Robert H., Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 296, 3, 2009. Crossref

  76. Zapara T. A., Proskura A. L., Malakhin I. A., Vechkapova S. O., Ratushnyak A. S., The Mobility of AMPA-Type Glutamate Receptors as a Key Factor in the Expression and Maintenance of Synaptic Potentiation, Neuroscience and Behavioral Physiology, 47, 5, 2017. Crossref

  77. Choudhary Arbind Kumar, Lee Yeong Yeh, Neurophysiological symptoms and aspartame: What is the connection?, Nutritional Neuroscience, 21, 5, 2018. Crossref

  78. Sepulveda Fernando J., Bustos Fernando J., Inostroza Eveling, Zúñiga Felipe A., Neve Rachael L., Montecino Martin, van Zundert Brigitte, Differential Roles of NMDA Receptor Subtypes NR2A and NR2B in Dendritic Branch Development and Requirement of RasGRF1, Journal of Neurophysiology, 103, 4, 2010. Crossref

  79. Tran Phu V., Dakoji Srikanth, Reise Kathryn H., Storey Kathleen K., Georgieff Michael K., Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 305, 11, 2013. Crossref

  80. Chatterjea Debika, Hamid Edaeni, Leonard John P., Alford Simon, Phosphorylation-State-Dependent Regulation of NMDA Receptor Short-Term Plasticity Modifies Hippocampal Dendritic Ca2+ Transients, Journal of Neurophysiology, 104, 4, 2010. Crossref

  81. Lee Myunghwan, Kwon Taegeon, Kim Sujin, Kim Saeyoung, Park Kibum, Jeon Younghoon, Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection, Medicine, 96, 10, 2017. Crossref

  82. Wright Jason, Campos Carlos, Herzog Thiebaut, Covasa Mihai, Czaja Krzysztof, Ritter Robert C., Reduction of food intake by cholecystokinin requires activation of hindbrain NMDA-type glutamate receptors, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 301, 2, 2011. Crossref

  83. Zhu Zhi-ru, Xu Fenglian, Ji Wei-gang, Ren Shuan-cheng, Chen Fang, Chen Peng-zhi, Jiang Hui-hui, Mi Ze, Hu Bo, Zhang Jun, Xiong Ying, Synaptic mechanisms underlying thalamic activation-induced plasticity in the rat auditory cortex, Journal of Neurophysiology, 111, 9, 2014. Crossref

  84. Sheridan Graham K., Moeendarbary Emad, Pickering Mark, O'Connor John J., Murphy Keith J., Norris Christopher Mark, Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning, PLoS ONE, 9, 6, 2014. Crossref

  85. Mao Li-Min, Wang John Q., Antagonism of Dopamine D2 Receptors Alters Phosphorylation of Fyn in the Rat Medial Prefrontal Cortex, Journal of Molecular Neuroscience, 61, 4, 2017. Crossref

  86. Chakraborty Mukta, Chen Liang-Fu, Fridel Emma E., Klein Marguerita E., Senft Rebecca A., Sarkar Abhra, Jarvis Erich D., Overexpression of human NR2B receptor subunit in LMAN causes stuttering and song sequence changes in adult zebra finches, Scientific Reports, 7, 1, 2017. Crossref

  87. Zhao Fuqiang, Wang Xiaohai, Zariwala Hatim A., Uslaner Jason M., Houghton Andrea K., Evelhoch Jeffrey L., Hostetler Eric, Winkelmann Christopher T., Hines Catherine D.G., fMRI study of the role of glutamate NMDA receptor in the olfactory adaptation in rats: Insights into cellular and molecular mechanisms of olfactory adaptation, NeuroImage, 149, 2017. Crossref

  88. Esposito Susanna, Principi Nicola, Calabresi Paolo, Rigante Donato, An evolving redefinition of autoimmune encephalitis, Autoimmunity Reviews, 18, 2, 2019. Crossref

  89. Huang Sun, Chen Lina, Bladen Chris, Stys Peter K., Zamponi Gerald W., Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions, Molecular Brain, 11, 1, 2018. Crossref

  90. Waters Elizabeth M., Mazid Sanoara, Dodos Mariana, Puri Rishi, Janssen William G., Morrison John H., McEwen Bruce S., Milner Teresa A., Effects of estrogen and aging on synaptic morphology and distribution of phosphorylated Tyr1472 NR2B in the female rat hippocampus, Neurobiology of Aging, 73, 2019. Crossref

  91. Grosshans David R., Duman Joseph G., Gaber M. Waleed, Sawakuchi Gabriel, Particle Radiation Induced Neurotoxicity in the Central Nervous System, International Journal of Particle Therapy, 5, 1, 2018. Crossref

  92. Wang Xue-Ying, Zhou Hui-Ru, Wang Sha, Liu Chao-Yang, Qin Guang-Cheng, Fu Qing-Qing, Zhou Ji-Ying, Chen Li-Xue, NR2B-Tyr phosphorylation regulates synaptic plasticity in central sensitization in a chronic migraine rat model, The Journal of Headache and Pain, 19, 1, 2018. Crossref

  93. Talebian Asghar, Robinson-Brookes Kim, Meakin Susan O., TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1, Journal of Molecular Neuroscience, 67, 1, 2019. Crossref

  94. Zhang Die, Zhou Wei, Lam Thanh Thai, Weng Connie, Bronk Lawrence, Ma Duo, Wang Qiang, Duman Joseph G, Dougherty Patrick M, Grosshans David R, Radiation induces age-dependent deficits in cortical synaptic plasticity, Neuro-Oncology, 20, 9, 2018. Crossref

  95. Gonzalez Fernando F., Neuroprotection Strategies for Term Encephalopathy, Seminars in Pediatric Neurology, 32, 2019. Crossref

  96. Gidon Albert, Biophysics of Synaptic Inhibition in Dendrites, in The Computing Dendrite, 11, 2014. Crossref

  97. MacDonald John F., Belrose Jillian C., Xie Yu-Feng, Jackson Michael F., Nonselective Cation Channels and Links to Hippocampal Ischemia, Aging, and Dementia, in Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications, 961, 2013. Crossref

  98. Müller Werner, Frings Stephan, Lernen, Gedächtnis, prägende Erfahrung, in Tier- und Humanphysiologie, 2009. Crossref

  99. Bodkin J. Alexander, Coleman Michael J., Godfrey Laura J., Carvalho Claudia M.B., Morgan Charity J., Suckow Raymond F., Anderson Thea, Öngür Dost, Kaufman Marc J., Lewandowski Kathryn E., Siegel Arthur J., Waldstreicher Elliot, Grochowski Christopher M., Javitt Daniel C., Rujescu Dan, Hebbring Scott, Weinshilboum Richard, Rodriguez Stephanie Burgos, Kirchhoff Colette, Visscher Timothy, Vuckovic Alexander, Fialkowski Allison, McCarthy Shane, Malhotra Dheeraj, Sebat Jonathan, Goff Donald C., Hudson James I., Lupski James R., Coyle Joseph T., Rudolph Uwe, Levy Deborah L., Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene, Biological Psychiatry, 86, 7, 2019. Crossref

  100. Medeiros Priscila, Negrini-Ferrari Sylmara Esther, Palazzo Enza, Maione Sabatino, Ferreira Sérgio Henrique, de Freitas Renato Leonardo, Coimbra Norberto Cysne, N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain, Neurochemical Research, 44, 9, 2019. Crossref

  101. Clapp Peter, Gibson Emily S., Dell'Acqua Mark L., Hoffman Paula L., Phosphorylation Regulates Removal of Synaptic N-Methyl-d-Aspartate Receptors after Withdrawal from Chronic Ethanol Exposure, Journal of Pharmacology and Experimental Therapeutics, 332, 3, 2010. Crossref

  102. Kabir Md. Tanvir, Sufian Mohammad A., Uddin Md. Sahab, Begum Mst. Marium, Akhter Shammi, Islam Ariful, Mathew Bijo, Islam Md. Siddiqul, Amran Md. Shah, Md. Ashraf Ghulam, NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy, Current Pharmaceutical Design, 25, 33, 2019. Crossref

  103. Liu Jinping, Chang Lirong, Song Yizhi, Li Hui, Wu Yan, The Role of NMDA Receptors in Alzheimer’s Disease, Frontiers in Neuroscience, 13, 2019. Crossref

  104. Benquet Pascal, Gee Christine E., Gerber Urs, lschémie cérébrale, médecine/sciences, 24, 2, 2008. Crossref

  105. Wende Kim C., Jansen Andreas, Top-down and/or Bottom-up Causality: The Notion of Relatedness in the Human Brain, in Advances in Cognitive Neurodynamics (V), 2016. Crossref

  106. Holahan Matthew R., Tzakis Niko, Oliveira Fernando A., Developmental Aspects of Glucose and Calcium Availability on the Persistence of Memory Function Over the Lifespan, Frontiers in Aging Neuroscience, 11, 2019. Crossref

  107. Huang Sheng-Nan, Wei Jinbao, Huang Lan-Ting, Ju Pei-Jun, Chen Jinghong, Wang Yong-Xiang, Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A, Neural Plasticity, 2020, 2020. Crossref

  108. Zhao Yang, He Jianshuai, Yu Ning, Jia Changxin, Wang Shilei, Mechanisms of Dexmedetomidine in Neuropathic Pain, Frontiers in Neuroscience, 14, 2020. Crossref

  109. Seo Joo Hee, Lee Yun-Jin, Lee Ki Hyeong, Gireesh Elakkat, Skinner Holly, Westerveld Michael, Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum, Clinical and Experimental Pediatrics, 63, 8, 2020. Crossref

  110. Johnson Abbie C., Li Zhaojin, Orfila James E., Herson Paco S., Cipolla Marilyn J., Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia, Progress in Neurobiology, 199, 2021. Crossref

  111. Rossi Franca, Valentina Casazza, Garavaglia Silvia, Sathyasaikumar Korrapati V., Schwarcz Robert, Kojima Shin-ichi, Okuwaki Keisuke, Ono Shin-ichiro, Kajii Yasushi, Rizzi Menico, Crystal Structure-Based Selective Targeting of the Pyridoxal 5′-Phosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement, Journal of Medicinal Chemistry, 53, 15, 2010. Crossref

  112. Burnell Erica S., Irvine Mark, Fang Guangyu, Sapkota Kiran, Jane David E., Monaghan Daniel T., Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure–Activity Relationships and Mechanisms of Action, Journal of Medicinal Chemistry, 62, 1, 2019. Crossref

  113. Hamilton Alison, Zamponi Gerald W, Ferguson Stephen S G, Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes, Molecular Brain, 8, 1, 2015. Crossref

  114. Das Ishita, Reeves Roger H., The use of mouse models to understand and improve cognitive deficits in Down syndrome, Disease Models & Mechanisms, 4, 5, 2011. Crossref

  115. Postnikova Tatyana Y., Diespirov Georgy P., Amakhin Dmitry V., Vylekzhanina Elizaveta N., Soboleva Elena B., Zaitsev Aleksey V., Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy, International Journal of Molecular Sciences, 22, 24, 2021. Crossref

  116. Lemtiri-Chlieh Fouad, Zhao Liangfang, Kiraly Drew D, Eipper Betty A, Mains Richard E, Levine Eric S, Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity, BMC Neuroscience, 12, 1, 2011. Crossref

  117. Wickström Ronny, Fowler Åsa, Goiny Michel, Millischer Vincent, Ygberg Sofia, Schwieler Lilly, The Kynurenine Pathway is Differentially Activated in Children with Lyme Disease and Tick-Borne Encephalitis, Microorganisms, 9, 2, 2021. Crossref

  118. Watkins Jeffrey C., Evans Richard H., Bayés Àlex, Booker Sam A., Gibb Alasdair, Mabb Angela M., Mayer Mark, Mellor Jack R., Molnár Elek, Niu Li, Ortega Arturo, Pankratov Yuriy, Ramos-Vicente David, Rodríguez-Campuzano Ada, Rodríguez-Moreno Antonio, Wang Lu-Yang, Wang Yu Tian, Wollmuth Lonnie, Wyllie David J.A., Zhuo Min, Frenguelli Bruno G., 21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans, Neuropharmacology, 198, 2021. Crossref

  119. Sitnikov Ivan Andreevich, Shaikhova Daria Ramilevna, Amromina Anna Mikhailovna, Sutunkova Marina Petrovna, Ryabova Yuliya Vladimirovna, Tazhigulova Anastasiya Valerevna, Ruzakov Vadim Olegovich, Effect of copper oxide nanoparticles on gene expression of NMDA receptor, Toxicological Review, 29, 6, 2021. Crossref

  120. Cuestas Torres Diana Marcela, Cardenas Fernando P., Synaptic plasticity in Alzheimer’s disease and healthy aging, Reviews in the Neurosciences, 31, 3, 2020. Crossref

  121. Belrose Jillian Corinne, Jackson Michael Frederick, TRPM2: a candidate therapeutic target for treating neurological diseases, Acta Pharmacologica Sinica, 39, 5, 2018. Crossref

  122. Wu Xiu-Lin, Yan Qiu-Jin, Zhu Fan, Abnormal synaptic plasticity and impaired cognition in schizophrenia, World Journal of Psychiatry, 12, 4, 2022. Crossref

  123. Xiao Ling-Yong, Wang Xue-Rui, Ye Yang, Yang Jing-Wen, Cao Yan, Ma Si-Ming, Li Tian-Ran, Liu Cun-Zhi, Applications of Acupuncture Therapy in Modulating Plasticity of Central Nervous System, Neuromodulation: Technology at the Neural Interface, 21, 8, 2018. Crossref

  124. Scampoli Claudia, Cammelli Silvia, Galietta Erika, Siepe Giambattista, Buwenge Milly, Macchia Gabriella, Deodato Francesco, Cilla Savino, Strigari Lidia, Chiesa Silvia, Morganti Alessio Giuseppe, Memantine in the Prevention of Radiation-Induced Brain Damage: A Narrative Review, Cancers, 14, 11, 2022. Crossref

  125. Kong Erliang, Li Yongchang, Deng Mengqiu, Hua Tong, Yang Mei, Li Jian, Feng Xudong, Yuan Hongbin, Glycometabolism Reprogramming of Glial Cells in Central Nervous System: Novel Target for Neuropathic Pain, Frontiers in Immunology, 13, 2022. Crossref

  126. Holbro Niklaus, Grunditz Åsa, Oertner Thomas G., Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses, Proceedings of the National Academy of Sciences, 106, 35, 2009. Crossref

  127. You Haitao, Tsutsui Shigeki, Hameed Shahid, Kannanayakal Thomas J., Chen Lina, Xia Peng, Engbers Jordan D. T., Lipton Stuart A., Stys Peter K., Zamponi Gerald W., Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N -methyl- d -aspartate receptors , Proceedings of the National Academy of Sciences, 109, 5, 2012. Crossref

  128. Mohanan Archana G., Gunasekaran Sowmya, Jacob Reena Sarah, Omkumar R. V., Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses, Frontiers in Molecular Neuroscience, 15, 2022. Crossref

  129. Rensing Ludger, Koch Michael, Becker Annette, A comparative approach to the principal mechanisms of different memory systems, Naturwissenschaften, 96, 12, 2009. Crossref

  130. Wiatrak Benita, Mieszała Przemysław, Gąsiorowski Kazimierz, Impact of NMDA receptor activation on DNA damage in PC12 neuron-like cell cultures in the presence of β-amyloid peptides, Molecular Biology Reports, 49, 11, 2022. Crossref

  131. Duarte-Silva A. T., Ximenes L. G. R., Guimarães-Souza M., Domith I., Paes-de-Carvalho R., Chemical signaling in the developing avian retina: Focus on cyclic AMP and AKT-dependent pathways, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain