Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Critical Reviews™ in Neurobiology

ISSN Imprimir: 0892-0915
ISSN En Línea: 2375-0014

Archives: Volume 10, 1996 to Volume 20, 2008

Critical Reviews™ in Neurobiology

DOI: 10.1615/CritRevNeurobiol.v14.i1.10
21 pages

Cognitive Impairment in Schizophrenia Is the Core of the Disorder

Brita Elvevag
Clinical Brain Disorders Branch, National Institute of Mental Health/National Institutes of Health, Building 10, Room 4S235, Bethesda, MD 20892
Terry E. Goldberg
Clinical Brain Disorders Branch Neurosciences Center at St. Elizabeths Washington, DC 20032; and National Institute of Mental Health/National Institutes of Health, Building 10, Room 4S235, Bethesda, MD 20892


Patients with schizophrenia exhibit an exceedingly wide range of symptoms from a variety of domains. The cardinal features are abnormal ideas (such as delusions); abnormal perceptions (such as hallucinations); formal thought disorder (as evidenced by disorganized speech); motor, volitional, and behavioral disorders; and emotional disorders (such as affective flattening or inappropriateness). In addition to these diverse, and sometimes bizarre symptoms, it has become increasingly apparent that the disorder is, to variable degrees, accompanied by a broad spectrum of cognitive impairments. This review addresses the question of whether the cognitive deficits seen in schizophrenic patients are the core features of the disorder. In other words, we explore whether schizophrenia is best characterized by symptoms or cognitive deficits (we suggest the latter) and moreover, whether there is a specific cognitive deficit profile that may assist in diagnosis. First, we discuss what the cognitive deficits are. Then we address in turn the reality, frequency, predictive validity, specificity, course and susceptibility to neuroleptic effects of these cognitive impairments. In brief, we argue that various cognitive deficits are enduring features of the schizophrenia illness, that they are not state-related and are not specific to subtypes of the illness, and, more specifically, that working memory and attention are characteristically impaired in patients with schizophrenia, irrespective of their level of intelligence. Last, we conclude that problems in these cognitive domains are at the very core of the dysfunction in this disease.

Articles with similar content:

Multiple Chemical Sensitivity: Potential Role for Neural Sensitization
Critical Reviews™ in Neurobiology, Vol.13, 1999, issue 3
Barbara A. Sorg
Abstract of "Ethical, Legal, and Social Issues in Neurotechnology Research: Confronting the Boundaries and Considering the Implications"
Journal of Long-Term Effects of Medical Implants, Vol.18, 2008, issue 1
Dennis K. McBride
Clinical Features and Rehabilitation of Strokes in the Less Common Vascular Territories: Anterior and Posterior Cerebral Artery Strokes
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.19, 2007, issue 4
Yee Sien Ng
Disability and Impairment in Fibromyalgia Syndrome: Possible Pathogenesis and Etiology
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.7, 1995, issue 3
Jessica Elert, Bjorn Gerdle
Locomotion in Patients with Spinal Cord Injury
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.12, 2000, issue 2
V. Dietz