RT Journal Article ID 03cfd7587fcdaecc A1 Horn, Kerstin A1 Beier, Oliver A1 Wiegand, Cornelia A1 Laaouina, Abdelkhalil A1 Fink, Sarah A1 Pfuch, Andreas A1 Schimanski, Arnd A1 Grünler, Bernd A1 Hipler, Uta-Christina T1 Screening Test of a New Pulsed Plasma Jet for Medical Application JF Plasma Medicine JO PMED YR 2017 FD 2017-12-18 VO 7 IS 2 SP 133 OP 145 K1 cold atmospheric pressure plasma K1 plasma characterization K1 antimicrobial effect K1 dermatology K1 skin model AB Plasma sources in practice as medical devices must be certified according to strict safety standards. The present study analyzes the potential of a cold atmospheric pressure (CAP) jet for medical and specialized dermatological applications. We characterize plasma properties and investigate antimicrobial and cytotoxic effects. Plasma treatment of bacteria and fungi is performed using plasma mefenamic acid (MEF) (Tigres GmbH; Marschacht, Germany) pulsed technology. To evaluate the effects on biological materials, plasma process gas, input power, and treatment time were varied. The same treatments were realized on three-dimensional skin models to study cytotoxic effects. Treatment of bacteria and fungi with the plasma source of plasma MEF pulsed, with its cold potential-free plasma, shows a definite dependence on the kind of process gas used, plasma input power, and treatment time. Low plasma doses exhibit good cell compatibility for short, locally fixed treatment times. The CAP jet source of plasma MEF pulsed, using air or nitrogen as the process gas, seems to be suitable for medical and especially dermatological applications. In our study, it was possible to identify a range of useful therapeutic parameters with good antibacterial efficacy and without cytotoxic effects. PB Begell House LK https://www.dl.begellhouse.com/journals/5a5b4a3d419387fb,0b20c44d2e33f6aa,03cfd7587fcdaecc.html