RT Journal Article ID 1338832d19d3ddad A1 Mohsin, Mohammed A1 Negi, Prem Singh A1 Ahmed, Zakwan T1 Determination of the Antioxidant Activity and Polyphenol Contents of Wild Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt. Fr.) P. Karst. (Higher Basidiomycetes) from Central Himalayan Hills of India JF International Journal of Medicinal Mushrooms JO IJM YR 2011 FD 2011-12-15 VO 13 IS 6 SP 535 OP 544 K1 medicinal mushrooms K1 Lingzhi or Reishi mushroom K1 Ganoderma lucidum K1 wild strain K1 in vitro cultured mycelia K1 antioxidant activity K1 nutraceutical development AB The antioxidant potential of wild strain of Lingzhi or Reishi medicinal mushroom Ganoderma lucidum from Central Himalayan Hills (2000 m MSL) was evaluated, and compared with its in vitro cultured mycelia grown on malt extract broth in the laboratory. Antioxidant activities of both wild and cultivated G. lucidum in terms of IC50 (mg/ mL) were determined against different in vitro radical systems such as DPPH (1, 1-diphenyl-2-picrylhydrazyl), ABTS [2,2’-azinobis (3-ethylenebenzothiazoline-6-sulphonic acid)] and hydroxyl radicals, in addition to ferric reducing antioxidant power assay. Polyphenol contents were also determined, in order to assess their effects on the antioxidant activity of extracts. All the extracts showed significant antioxidant activity, and maximum scavenging was observed in the case of methanolic extracts of wild G. lucidum with minimum IC50 values 0.953 ± 0.040, 0.690 ± 0.014 and 3.295 ± 0.027 mg/mL, respectively, for DPPH, ABTS, and hydroxyl radicals. The efficacy of wild G. lucidum as a rich source of natural antioxidant was established for nutraceutical development. PB Begell House LK https://www.dl.begellhouse.com/journals/708ae68d64b17c52,7b5e519241ca8193,1338832d19d3ddad.html