%0 Journal Article %A Fomenko, I. S. %A Bondarchuk, T. I. %A Biletska, L. P. %A Panasyuk, N. B. %A Sklyarov, Oleksandr Ya. %D 2015 %I Begell House %K nonsteroidal anti-inflammatory drugs, stress, nitric oxide, gastric mucosa %N 4 %P 269-276 %R 10.1615/IntJPhysPathophys.v6.i4.10 %T Peculiarities of Effects of Nonsteroidal Anti-inflammatory Drugs on NO-synthase System in Gastric Mucosa of Rats under Stress Conditions %U https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,679181e944e2acd1,14f1c4ca2348d8e2.html %V 6 %X In experiments on rats with immobilization stress combined with water immersion, effects of nonsteroidal anti-inflammatory drugs (NSAIDs) of different genesis on the morphological status of gastric mucosa and changes in NO-synthase system activity were studied. An administration of naproxen, noncelective cyclooxygenase inhibitor, to rats with water-restrained stress enhanced strucrural hemorrhagic gastric mucosal lesions. At that, the activities of both isoforms of NO-sythase (inducible and constitutive) decreased, but lipoperoxidation processes remained at the level of stress. The advantage of using H2S-releasing nonsteroidal anti-inflammatory drug ATB-346 is a cytoprotective effect of the latter manifested as a decrease in total area of gastric injury. However, lipoperoxidation processes and NO-syntase activity did not differ substantially from those in the group treated with napoxen, indicating the prevalence of parent molecule (naproxen) in the regulation of NO-system functioning. An administration of a compound 2A5DHT, a dual COX/LOX inhibitor, caused the decrease in gastric injury as compared to naproxen influence. An activity of iNOS remained much higher than under condition of naproxen action. %8 2015-12-23