%0 Journal Article %A Gershkovich, Pavel %A Wasan, Kishor M. %A Barta, Cheri A. %D 2008 %I Begell House %N 6 %P 545-584 %R 10.1615/CritRevTherDrugCarrierSyst.v25.i6.20 %T A Review of the Application of Lipid-Based Systems in Systemic, Dermal/ Transdermal, and Ocular Drug Delivery %U https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,6d9016640bf024d0,17133f83644e9f00.html %V 25 %X The introduction of combinatorial chemistry and the development of high-throughput techniques has significantly increased the amount of new active lipophilic molecular entities. As a result, the need for successful delivery of these lipophilic active compounds has also increased. One such method of delivery is through the use of advanced lipid-based drug delivery systems. Traditionally, the majority of reviews of lipid-based drug delivery systems were based on the oral administration field only. This review article focuses on the use of lipids in parenteral, dermal/ transdermal, and ocular drug delivery systems. Specific needs, considerations, approaches, and limitations in lipid-based drug delivery are discussed herein on the basis of the anatomical and physiological diversity of the target organs and systems. %8 2008-12-20