RT Journal Article ID 2a93e3a12bdb71e5 A1 Iyer, Shankar Subramanian A1 Cheng, Gehong T1 Role of Interleukin 10 Transcriptional Regulation in Inflammation and Autoimmune Disease JF Critical Reviews™ in Immunology JO CRI YR 2012 FD 2012-03-14 VO 32 IS 1 SP 23 OP 63 K1 immune response K1 tissue homeostasis K1 interferon K1 persistent viral infection K1 tolerance K1 interleukin 27 AB Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,76944bab5ddebfc1,2a93e3a12bdb71e5.html