RT Journal Article ID 38a2ff3543c4af91 A1 Goswami, Tarun A1 Jasti, Bhaskara R. A1 Li, Xiaoling T1 Sublingual Drug Delivery JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2008 FD 2008-09-06 VO 25 IS 5 SP 449 OP 484 AB The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation. Attempts have been made to deliver various pharmacologically active agents, such as cardiovascular drugs, analgesics, and peptides, across the sublingual mucosa. In this review, the anatomical structure, blood supply, biochemical composition, transport pathways, permeation enhancement strategies, in vitro / in vivo models, and clinical investigations for the sublingual route of drug delivery is discussed. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,5c6300a248a5f5e1,38a2ff3543c4af91.html