RT Journal Article ID 3ac75dcc598ab0e0 A1 Bilzer , Thomas A1 Stitz , Lothar T1 Immunopathogenesis of Virus Diseases Affecting the Central Nervous System JF Critical Reviews™ in Immunology JO CRI YR 1996 FD 1996-06-30 VO 16 IS 2 SP 145 OP 222 K1 virus K1 infection K1 immune reaction K1 immunopathology K1 central nervous system K1 disease. AB A variety of viruses can cause diseases of the central nervous system by two different mechanisms. Cytolytic viruses exert direct effects on cells of the nervous system that result in death and cell loss. Noncytolytic viruses do not directly damage cells, but might harm cell functions in the long run. However, more common is the reaction of the immune system towards viral antigens of those noncytolytic viruses which ultimately might lead to an immunopathological disease. Several peculiarities of the central nervous system with regard to an immune reaction within this organ are discussed in the context of viral infections. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,768eb89a296943bc,3ac75dcc598ab0e0.html