RT Journal Article
ID 3b3fc454785e79ff
A1 Guse, Andreas H.
T1 Ca2+ Signaling in T-Lymphocytes
JF Critical Reviews™ in Immunology
JO CRI
YR 1998
FD 1998-10-30
VO 18
IS 5
SP 419
OP 448
K1 signal transduction
K1 Ca2+ signaling
K1 second messenger
K1 inositol 1,4,5-trisphosphate
K1 cyclic ADP-ribose
K1 T-lymphocytes.
AB Ca2+ signaling in response to antigenic stimulation is essential for proliferation of T cells and therefore is one of the important early events in T-lymphocyte signal transduction. Several aspects of T cell receptor/CD3 complex stimulated Ca2+ signaling are reviewed: generation, metabolism, function, and intracellular targets of the Ca2+-mobilizing second messengers inositol 1,4,5-trisphosphate and cyclic ADP-ribose, the mechanism of Ca2+ entry, and the generation of Ca2+ oscillations on the single cell level. In addition, Ca2+ signaling induced by further stimuli is discussed, including other T-lymphocyte surface receptors (e.g., CD4 or β1-integrins, lipids, and physical stimuli).
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,268361ca0b570ac9,3b3fc454785e79ff.html