RT Journal Article ID 3b3fc454785e79ff A1 Guse, Andreas H. T1 Ca2+ Signaling in T-Lymphocytes JF Critical Reviews™ in Immunology JO CRI YR 1998 FD 1998-10-30 VO 18 IS 5 SP 419 OP 448 K1 signal transduction K1 Ca2+ signaling K1 second messenger K1 inositol 1,4,5-trisphosphate K1 cyclic ADP-ribose K1 T-lymphocytes. AB Ca2+ signaling in response to antigenic stimulation is essential for proliferation of T cells and therefore is one of the important early events in T-lymphocyte signal transduction. Several aspects of T cell receptor/CD3 complex stimulated Ca2+ signaling are reviewed: generation, metabolism, function, and intracellular targets of the Ca2+-mobilizing second messengers inositol 1,4,5-trisphosphate and cyclic ADP-ribose, the mechanism of Ca2+ entry, and the generation of Ca2+ oscillations on the single cell level. In addition, Ca2+ signaling induced by further stimuli is discussed, including other T-lymphocyte surface receptors (e.g., CD4 or β1-integrins, lipids, and physical stimuli). PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,268361ca0b570ac9,3b3fc454785e79ff.html