RT Journal Article ID 3f62c3931ce902a2 A1 Opanasenko, Anna V. A1 Bratus, Larisa. V. A1 Gavenauskas, Bronislav L. A1 Gonchar, Olga A. A1 Mankovskaya, Irina N. A1 Nosar, Valentina I. A1 Frantsuzova, Stella B. T1 Disorders of Oxygen-Dependent Processes in Periodontal Tissues under Prolonged Immobilization Stress and the Ways of Their Pharmacological Correction JF International Journal of Physiology and Pathophysiology JO IJPP YR 2013 FD 2013-12-06 VO 4 IS 4 SP 315 OP 324 K1 immobilization stress K1 periodontal tissues K1 oxygen tension K1 oxygen consumption K1 mitochondria K1 pro-/antioxidant balance K1 Thiotriazolin K1 Actovegin AB The effects of prolonged immobilization (6 h strict horizontal position of rats in the tight containers daily for 2 weeks) on oxygen tension in the gingival tissue, oxygen consumption by the mandible alveolar bone, pro-/antioxidant balance and energetic metabolism of soft periodontal tissues were investigated. It has been shown that prolonged immobilization stress results in a marked decrease in the gingival tissue PO2 (by 36%), oxygen consumption rate in the bone tissue (by 46%), and a reduction in the gingival mitochondrial respiration rate, compared to the control values. The latter is more significantly manifested in case of oxidation of α-ketoglutarate, NAD-dependent substrate of the respiratory chain, compared to succinate, FAD-dependent one. The prolonged stress results in intensification of peroxide processes and a depletion of antioxidant protection of the soft periodontal tissues. It has been found that pharmacological drugs Thiotriazolin and Actovegin possess modifying protective effect on stress-induced disorders of oxygen homeostasis in the soft and hard periodontal tissues under prolonged immobilization stress. PB Begell House LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,43ae9da465f663ff,3f62c3931ce902a2.html