RT Journal Article ID 559c6f2b79527287 A1 Dhaeze, Tessa A1 Hellings, Niels T1 Circulating Follicular Regulatory T Cells in Autoimmune Diseases and Their Waning in Multiple Sclerosis JF Critical Reviews™ in Immunology JO CRI YR 2016 FD 2017-05-31 VO 36 IS 6 SP 511 OP 522 K1 circulating follicular regulatory T cells K1 autoimmune disease K1 germinal center K1 follicular helper T cells K1 multiple sclerosis K1 therapy AB Follicular regulatory T cells (TFRs) are a subset of regulatory T cells that reside in the secondary lymphoid organs and participate in controlling the germinal center (GC) response. The GC response forms the basis of adaptive immunity to foreign protein antigens. In autoimmune diseases, hyperreactivity to self-antigens occurs that may result from an aberrant control of the GC response. TFR dysfunctionality may be one of the factors contributing to this breakdown of self-tolerance. In this review, we discuss how the investigation of circulating TFRs can help us understand their relative contribution to autoimmune-mediated disease processes. Multiple sclerosis is taken as a classical example of autoimmune disease. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,556ac5b96519764b,559c6f2b79527287.html