RT Journal Article
ID 559c6f2b79527287
A1 Dhaeze, Tessa
A1 Hellings, Niels
T1 Circulating Follicular Regulatory T Cells in Autoimmune Diseases and Their Waning in Multiple Sclerosis
JF Critical Reviews™ in Immunology
JO CRI
YR 2016
FD 2017-05-31
VO 36
IS 6
SP 511
OP 522
K1 circulating follicular regulatory T cells
K1 autoimmune disease
K1 germinal center
K1 follicular helper T
cells
K1 multiple sclerosis
K1 therapy
AB Follicular regulatory T cells (TFRs) are a subset of regulatory T cells that reside in the secondary lymphoid organs and participate in controlling the germinal center (GC) response. The GC response forms the basis of adaptive immunity to foreign protein antigens. In autoimmune diseases, hyperreactivity to self-antigens occurs that
may result from an aberrant control of the GC response. TFR dysfunctionality may be one of the factors contributing to this breakdown of self-tolerance. In this review, we discuss how the investigation of circulating TFRs can help us understand their relative contribution to autoimmune-mediated disease processes. Multiple sclerosis is taken as a classical example of autoimmune disease.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,556ac5b96519764b,559c6f2b79527287.html