RT Journal Article
ID 55cf1992505a3c1f
A1 Jansson, Andreas
A1 Larsson, Dennis
A1 Holmen, Jonathan
T1 A Kinetic Overview of the Receptors Involved in 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 Signaling: A Systems Biology Approach
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2009
FD 2009-06-26
VO 19
IS 3
SP 181
OP 196
K1 vitamin D
K1 mathematical modeling
K1 nVDR
K1 PDIA3
K1 catalase
K1 receptor kinetics
AB The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D−dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,12b6e91c2627fc7a,55cf1992505a3c1f.html