RT Journal Article
ID 5e6d68dd67480289
A1 Doll, Bruce
A1 Sfeir, Charles
A1 Winn, Shelly R.
A1 Huard, John
A1 Hollinger, Jeffrey
T1 Critical Aspects of Tissue-Engineered Therapy for Bone Regeneration
JF Critical Reviews™ in Eukaryotic Gene Expression
JO CRE
YR 2001
FD 2001-05-01
VO 11
IS 1-3
OP 26
AB Recent advances in bone tissue engineering are established on the understanding of an engineered scaffold, the molecular milieu within the osteogenic site, and the cell(s) predisposed to an osteogenic lineage. Advances in the incorporation of a generative vehicle into a skeletal defect require temporal and spatial distribution of the scaffold, growth factor, and cell compatible with enhanced bone healing. Monitoring events culminating in osteogenesis has focused on phenotypic and intracellular indicators. Phenotypic and intracellular indicators include the presence of receptors and intracellular signals that enable cell proliferation and differentiation. Progress in the areas of scaffold design, growth factor utilization, bone cell lineage, and intracellular signaling are reviewed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/6dbf508d3b17c437,19f7208b154f3e8e,5e6d68dd67480289.html